137138-18-2

Basic information

• Product Name: 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin
• CAS NO: 137138-18-2
• Molecular Weight: 355.44
• Mol File: 137138-18-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin(CAS DataBase Reference)
• NIST Chemistry Reference: 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin(137138-18-2)
• EPA Substance Registry System: 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin(137138-18-2)

Safety Data

• Hazardous Substances Data: 137138-18-2(Hazardous Substances Data)

Upstream product

• 603-00-9 proxyphylline 
• 10226-64-9 7-Acetonyltheophylline 
• 60-15-1 2-amino-1-phenylpropane 
• 137138-15-9 Propoxyphyllintosylat 

Downstream Products

• 51-64-9 dexamfetamine 
• 156-34-3 l-amphetamine 

Relevant articles and documents

Enantioselective biotransformation of a new theophylline derivative

Reductive amination of 4 with (RS)-2 is an improved method to obtain 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophylline (3) (ratio of diastereomers 1:1) compared with SN-displacement of proxyphyllintosylate with (RS)-2 (ratio of diastereomers 9:1). Due to steric hindrance 3 is no noteworthy prodrug for the intermediate formation of (RS)-2 in rats. The enantioselectivity of 2 after a single oral dose of 3 is determined in 24-h urine by HPLC on a Cyclobond-column using the isoindole derivatives, formed from o-phthalaldehyde, thioglycolic acid, and 2. The R(-)-amphetamine isomer is formed to a lesser amount (34.8%, range 32-37%) than the S(+)-isomer (65.2%, range 63-68%).