10228-40-7Relevant articles and documents
Reactions of Ketene Acetals; 12. A Regiospecific Synthesis of Anthragallols
Roberge, Guy,Brassard, Paul
, p. 381 - 383 (1981)
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The Chemical Structure and the Mutagenicity of Emodin Metabolites
Morooka, Nobuhisa,Nakano, Sonoko,Itoi, Noriko,Ueno, Yoshio
, p. 1247 - 1252 (2007/10/02)
Emodin (1,3,8-trihydroxy-6-methyl-9,10-anthraquinone) is a natural occuring anthraquinone formed in rhubarb and fungal metabolites.Emodin was transformed into 6 major metabolites by rat hepatic microsomes.The metabolites were identified as 2-hydroxyemodin, 4-hydroxyemodin, 5-hydroxyemodin, 7-hydroxyemodin, ω-hydroxyemodin, and emodic acid by comparison with the synthetic compounds using thin-layer chromatography.It was clear that 2-hydroxyemodin is a proximate mutagen as a synthetic compound by the Salmonella assay.Other metabolites, such as 5-hydroxyemodin and ω-hydroxyemodin, became active after metabolic activation, but 4-hydroxyemodin and emodic acid were inactive either in the presence or in the absence of the metabolic activation system.