102284-47-9Relevant academic research and scientific papers
PEPTIDE ELASTASE INHIBITORS AND METHODS
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, (2008/06/13)
Compounds useful as inhibitors of the enzyme elastase are of the following general formula: STR1 wherein Z is selected from the group consisting of R"O--Suc--where R" is lower alkyl of 1 to 3 carbon atoms and CF 3 CO--; X is oxygen or sulfur; R' is selected from the group consisting of straight or secondary branch-chained alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 3 carbon atoms, alkynyl of 2 to 4 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, and benzyl, and R is selected from the group consisting of susbstituted or unsubstituted phenyl wherein the substituents are selected from the group consisting of nitro, and pentafluoro; benzyl, CH 2 CF 2 CF 2 CF 3, 1-lower alkyl tetrazolyl, 1-phenyltetrazolyl, 2-thioxo-3-thiazolidinyl-, pyridyl and benzothiazolyl, provided that when R is paranitrophenyl, R' is other than tertiary-butyl, benzyl or cyclohexyl, and when X is sulfur, R is other than benzyl. "
Peptidyl Carbamates Incorporating Amino Acid Isosteres as Novel Elastase Inhibitors
Digenis, George A.,Agha, Bushra J.,Tsuji, Kiyoshi,Kato, Masayuki,Shinogi, Masaki
, p. 1468 - 1476 (2007/10/02)
The design and synthesis of 13 novel peptidyl carbamates are described.When tested for inhibitory activity toward porcine pancreatic elastase, trypsin, and chymotrypsin, six compounds were found to specifically inhibit lastase without affecting the other
