1022915-15-6Relevant articles and documents
Catalytic asymmetric addition of alkynylzinc reagents to nitrones
Konishi, Atsuko,Wei, Lin,Kobayashi, Masato,Fujinami, Shuhei,Ukaji, Yutaka,Inomata, Katsuhiko
, p. 44 - 45 (2007)
The catalytic asymmetric addition of alkynylzinc reagents, which were prepared in situ from dimethylzinc and 1-alkynes, to nitrones was achieved by utilizing di(t-butyl) (R,R)-tartrate as a chiral auxiliary to afford the corresponding optically active (R)
Asymmetric addition of alkynylzinc reagents to nitrones utilizing tartaric acid ester as a chiral auxiliary
Wei, Weilin,Kobayashi, Masato,Ukaji, Yutaka,Inomata, Katsuhiko
, p. 176 - 177 (2006)
The asymmetric addition of alkynylzinc reagents, prepared in situ from dialkylzinc and 1-alkynes, to nitrones was achieved by utilizing di(t-butyl) (R,R)-tartrate as a chiral auxiliary to afford the corresponding optically active (R)-α-substituted proparg
Synthesis of 4-Isoxazolines through Gold(I)-Catalyzed Cyclization of Propargylic N-Hydroxylamines
Chandrasekhar,Ahn, Sewon,Ryu, Jae-Sang
, p. 6740 - 6749 (2016/08/16)
New catalytic methods for the synthesis of 4-isoxazolines have been developed via catalytic intramolecular cyclizations of propargylic N-hydroxylamines. The reactions proceed rapidly in less than 1 h at room temperature in the presence of 5 mol % (PPh3)AuCl/5 mol % AgOTf or 5 mol % (PPh3)AuNTf2. This process features an efficient route to 4-isoxazolines with high yields, short reaction times, and mild reaction conditions.
Asymmetric addition of phenylzinc reagents to C-alkynyl nitrones. Enantiomeric enhancement by a product-like additive
Wei, Weilin,Hamamoto, Yoshihira,Ukaji, Yutaka,Inomata, Katsuhiko
, p. 476 - 481 (2008/09/19)
Asymmetric addition of diphenylzinc to C-alkynyl nitrones was achieved by utilizing di(t-butyl) (R,R)-tartrate as a chiral auxiliary to afford the corresponding optically active (S)-N-(1-phenyl-3-substituted prop-2-ynyl)hydroxylamines. By the addition of a product-like additive, enantiomeric enhancement was observed. A mixed zinc reagent, PhZnMe, improved the enantioselection to afford hydroxylamines in up to 92% ee.
