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2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1022945-74-9

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1022945-74-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1022945-74-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,2,9,4 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1022945-74:
(9*1)+(8*0)+(7*2)+(6*2)+(5*9)+(4*4)+(3*5)+(2*7)+(1*4)=129
129 % 10 = 9
So 1022945-74-9 is a valid CAS Registry Number.

1022945-74-9Relevant academic research and scientific papers

Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group

Milkiewicz, Karen L.,Aimone, Lisa D.,Albom, Mark S.,Angeles, Thelma S.,Chang, Hong,Grobelny, Jennifer V.,Husten, Jean,LoSardo, Christine,Miknyoczki, Sheila,Murthy, Seetha,Rolon-Steele, Damaris,Underiner, Ted L.,Weinberg, Linda R.,Worrell, Candace S.,Zeigler, Kelli S.,Dorsey, Bruce D.

, p. 6274 - 6284 (2011/12/15)

The hepatocyte growth factor (HGF)-c-Met signaling axis is involved in the mediation of many biological activities, including angiogenesis, proliferation, cell survival, cell motility, and morphogenesis. Dysregulation of c-Met signaling (e.g., overexpress

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