1023-94-5

Basic information

• Product Name: 1,1-diphenylbutane-1,4-diol
• Synonyms: 1,1-diphenylbutane-1,4-diol;1,1-Diphenyl-1,4-butanediol;Einecs 213-827-9;1,4-Butanediol, 1,1-diphenyl-
• CAS NO: 1023-94-5
• Molecular Formula: C₁₆H₁₈O₂
• Molecular Weight: 242.31292
• EINECS: 213-827-9
• Mol File: 1023-94-5.mol
• Article Data: 21

Chemical Properties

• Melting Point: 108 °C
• Boiling Point: 434.8 °C at 760 mmHg
• Flash Point: 208.1 °C
• Appearance: /
• Density: 1.131
• Vapor Pressure: 2.49E-08mmHg at 25°C
• Refractive Index: 1.588
• PKA: 13.40±0.29(Predicted)
• CAS DataBase Reference: 1,1-diphenylbutane-1,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-diphenylbutane-1,4-diol(1023-94-5)
• EPA Substance Registry System: 1,1-diphenylbutane-1,4-diol(1023-94-5)

Safety Data

• Hazardous Substances Data: 1023-94-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 19, p. 3013, 1978 DOI: 10.1016/S0040-4039(01)94926-3

InChI:InChI=1/C16H18O2/c17-13-7-12-16(18,14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,17-18H,7,12-13H2

Upstream product

• 39755-03-8 4-hydroxy-1-phenyl-butan-1-one 
• 100-58-3 phenylmagnesium bromide 
• 4165-79-1 1,1-diphenyl-3-buten-1-ol 
• 96-48-0 4-butanolide 
• 71-43-2 benzene 
• 119-61-9 benzophenone 
• 108-86-1 bromobenzene 
• 627-32-7 1-iodopropan-3-ol 
• 627-30-5 1-chloro-3-hydroxypropane 
• 29430-66-8 1,1-diphenyl-but-3-yn-1-ol 
• 29346-30-3 3-tributylstannyl-1-propanol 
• 1120-74-7 (RS)-2-chloro-4-hydroxy-butyraldehyde (RS)-cyclohemiacetal 
• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 
• 15807-08-6 1,1-diphenyl-but-2-yne-1,4-diol 

Downstream Products

• 1266656-50-1 4-(4-chloro-3-(trifluoromethyl)phenyl)-1-(4,4-diphenylbutyl)piperidin-4-ol 
• 36765-74-9 4,4-Diphenylbutylamine 
• 39755-02-7 4-phenoxy-1-phenylbutan-1-one 
• 14578-67-7 4,4-diphenylbutanoic acid 
• 16778-16-8 4-phenoxy-1,1-diphenylbutan-1-ol 
• 41343-21-9 4-hydroxy-1,4,4-triphenylbutan-1-one 
• 1392849-06-7 2,2-diphenyl-1,7-dioxaspiro[5.5]undecane 
• 1375014-94-0 2,2-diphenyl-1,7-dioxaspiro[5.5]undecane 
• 1375014-81-5 4-(3,4-dihydro-2H-pyran-6-yl)-1,1-diphenylbutan-1-ol 
• 1375014-80-4 C₂₄H₃₂O₂Si 
• 1375014-71-3 C₁₉H₂₆O₂Si 
• 3312-06-9 8-(4,4-diphenyl-butyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 36265-55-1 1,1-diphenyl-4-bromobutane 
• 1246448-18-9 4-(bis(4-methoxyphenyl)(phenyl)methoxy)-1,1-diphenylbutan-1-ol 

Relevant articles and documents

Convenient synthesis of 1,1-disubstituted 1,4-butanediols and derivatives.

-

-

-

DMSO-Enabled Selective Radical O?H Activation of 1,3(4)-Diols

Control of selectivity is one of the central topics in organic chemistry. Although unprecedented alkoxyl-radical-induced transformations have drawn a lot of attention, compared to selective C?H activation, selective radical O?H activation remains less explored. Herein, we report a novel selective radical O?H activation strategy of diols by combining spatial effects with proton-coupled electron transfer (PCET). It was found that DMSO is an essential reagent that enables the regioselective transformation of diols. Mechanistic studies indicated the existence of the alkoxyl radical and the selective interaction between DMSO and hydroxyl groups. Moreover, the distal C?C cleavage was realized by this selective alkoxyl-radical-initiation protocol.

Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity

Several recent reports have highlighted the feasibility of the use of penfluridol, a well-known antipsychotic agent, as a chemotherapeutic agent. In vivo experiments have confirmed the cytotoxic activity of penfluridol in triple-negative breast cancer model, lung cancer model, and further studies have been proposed to assess its anticancer activity and viability for the treatment of glioblastomas. However, penfluridol anticancer activity was observed at a dosage significantly higher than that administered in antipsychotic therapy, thus raising the concern for the potential onset of CNS side effects in patients undergoing intensive pharmacological treatment. In this study, we evaluate the potential CNS toxicity of penfluridol side by side with a set of analogs.