102308-62-3

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Nitrophenyl)-beta-alanine is used as a building block for the synthesis of novel pharmaceutical agents, contributing to the development of new drugs with potential therapeutic benefits.
Used in Organic Synthesis:
3-(4-Nitrophenyl)-beta-alanine is utilized in organic synthesis processes, where its unique structure and reactivity can be leveraged to create a variety of chemical products.
Used as a Research Tool:
In the field of scientific research, 3-(4-Nitrophenyl)-beta-alanine serves as a valuable tool for studying the properties and reactivity of beta-alanine derivatives, aiding in the understanding of their behavior and potential applications in various chemical and biological systems.

InChI:InChI=1/C9H10N2O4/c10-8(5-9(12)13)6-1-3-7(4-2-6)11(14)15/h1-4,8H,5,10H2,(H,12,13)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 141-82-2 malonic acid 
• 619-89-6 p-nitrocinnamic acid 
• 54267-71-9 3-(4-nitrophenyl)-2-carboxy-2-propenoic acid 
• 460039-81-0 3-amino-3-(4-nitrophenyl)-2-carboxypropanoic acid 
• 64-17-5 ethanol 
• 882-06-4 4-nitro-trans-cinnamic acid 
• 7803-49-8 hydroxylamine 
• 953-26-4 ethyl 4-nitrocinnamate 

Downstream Products

• 1269634-24-3 C₁₇H₁₆N₂O₅ 
• 1257211-86-1 (R)-1-[3-benzamido-3-(4-nitrophenyl)propanamido]-3-methylbutylboronic acid 
• 273920-24-4 methyl 3-amino-3-(4-nitrophenyl)propanoate 
• 273920-31-3 (RS)-3-(9-fluorenylmethoxycarbonylamino)-3-(4-nitrophenyl)propanoic acid 

Relevant academic research and scientific papers

Phenyl-oxamideHIV-1 inhibitors and preparation method and application thereof

The invention relates to phenyl-oxamideHIV-1 inhibitors and a preparation method and application thereof. Compounds have the structure shown in the formula I. The invention further relates to drug compositions containing the compounds with the structure s

Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase

In the last two decades, trans-sialidase of Trypanosoma cruzi (TcTS) has been an important pharmacological target for developing new anti-Chagas agents. In a continuous effort to discover new potential TcTS inhibitors, 3-amino-3-arylpropionic acid derivatives (series A) and novel phthaloyl derivatives (series B, C and D) were synthesized and molecular docking, TcTS enzyme inhibition and determination of trypanocidal activity were carried out. From four series obtained, compound D-11 had the highest binding affinity value (?11.1 kcal/mol) compared to reference DANA (?7.8 kcal/mol), a natural ligand for TS enzyme. Furthermore, the 3D and 2D interactions analysis of compound D-11 showed a hydrogen bond, π-π stacking, π-anion, hydrophobic and Van der Waals forces with all important amino acid residues (Arg35, Arg245, Arg314, Tyr119, Trp312, Tyr342, Glu230 and Asp59) on the active site of TcTS. Additionally, D-11 showed the highest TcTS enzyme inhibition (86.9% ± 5) by high-performance ion exchange chromatography (HPAEC). Finally, D-11 showed better trypanocidal activity than the reference drugs nifurtimox and benznidazole with an equal % lysis (63 ± 4 and 65 ± 2 at 10 μg/mL) and LC50 value (52.70 ± 2.70 μM and 46.19 ± 2.36 μM) on NINOA and INC-5 strains, respectively. Therefore, D-11 is a small-molecule with potent TcTS inhibition and a strong trypanocidal effect that could help in the development of new anti-Chagas agents.

β-alanine derivates

Alkanoic acid derivatives of formula (1) are described: [in-line-formulae]Ar1(Alka)rL1Ar2CH(R1)C(Ra)(Ra′)R??(1)[/in-line-formulae]Ar1 is an optionally subst

Enzymatic process for the enantiomeric resolution of amino acids

An enzymatic process permitting the enantiomeric resolution of amino acids is provided. More specifically, this process for separating the enantiomers of an amino acid comprises treating a racemic mixture of the amino acid with glutaric anhydride and then with the enzyme glutaryl-7-ACA acylase so as to recover one of the enantiomers of the amino acid, the other enantiomer remaining in the form of the corresponding glutarylamide derivative.

A one-pot synthesis of 3-amino-3-arylpropionic acids

3-Aminopropionic acids (β-amino acids) are biologically active compounds of interest in medicinal and pharmaceutical chemistry. Twenty-one 3-amino-3-arylpropionic acids were synthesized via a facile one-pot synthesis. In addition, a series of mechanistic studies have been performed to optimize the production of these β-amino acids. The reaction mechanism of this one-pot synthesis of β-amino acids, as well as the electronic effect of para-substitution and the influence of solvent polarity on the proposed reaction mechanism are discussed.

Substituted aryl ureas as high potency sweeteners

Substituted ureas and thioureas are disclosed for use as high potency sweeteners.