102322-83-8Relevant articles and documents
Precursors for fragrant ketones and fragrant aldehydes
-
, (2008/06/13)
The present invention refers to fragrance precursors of formula I for a fragrant ketone of formula II and one or more fragrant aldehydes or ketones of formula III and IV, These fragrance precursors are useful in perfumery, especially in the fine and functional perfumery.
A new protocol for a regioselective aldol condensation as an alternative convenient synthesis of β-ketols and α,β-unsaturated ketones
Kourouli, Therapia,Kefalas, Panagiotis,Ragoussis, Nikitas,Ragoussis, Valentine
, p. 4615 - 4618 (2007/10/03)
A general and convenient synthesis of β-ketols and α,β-alkenones has been achieved by a Knoevenagel condensation of a β-ketoacid with an aldehyde in aqueous medium. Saponification of a β-ketoester by an aqueous KOH 10% solution gives the potassium salt of the β-ketoacid, which is condensed in situ with an aldehyde at pH 7.8-8.0, at 60 °C for 5-6 h. The intermediate β-ketocarboxylate is smoothly decarboxylated in the reaction medium, giving the β-ketol in high yield (75-90%). Acidification of the reaction mixture at pH 1 and heating at 70 °C under vigorous stirring for 6 h, leads directly to the corresponding α,β-unsaturated ketone in good yield (65-75%).
Ketone precursors for organoleptic compounds
-
, (2008/06/13)
The invention discloses ketones of formula I: wherein, Y is an optionally substituted alkyl, cycloalkyl, or cycloalkylalkyl, wherein each alkyl group is straight or branched and each alkyl and cycloalkyl group is saturated or unsaturated; R1is hydrogen or a C1-6alkyl group that is substituted, saturated or unsaturated, straight or branched; A is a chromophoric substituted aromatic ring or ring system; n is an integer; and with the proviso that formula I is not 2-ethoxy-1-phenyl-ethanone. These compositions are useful for the delivery of organoleptic compounds, especially of flavors, fragrances, masking agents and antimicrobial compounds.
Process for the preparation of α,β-and β,γ-unsaturated ketones
-
, (2008/06/13)
α,β-and β,γ-unsaturated ketones of formula STR1 possessing a double bond in one of the positions indicated by the dashed lines and wherein R and R1 have the meaning given above and index n stands for integer 1 or 2, are obtained by a process which consists in treating with a strong base in an inert organic solvent a diallyl carbinol of formula STR2 wherein symbol R represents a primary, secondary or tertiary alkyl radical, or a substituted or unsubstituted phenyl radical, and symbol R1 represents a hydrogen atom or an alkyl radical.
FRAGMENTATION OF HOMOALLYLIC ALKOXIDES. SYNTHESIS OF PROPENYL and 2-METHYLPROPENYL KETONES FROM CARBOXYLIC ESTERS
Snowden, Roger L.,Muller, Bernard L.,Schulte-Elte, Karl H.
, p. 335 - 338 (2007/10/02)
An efficient two-step synthesis of propenyl and 2-methylpropenyl ketones from carboxylic esters is described which uses as the key step the fragmentation of a potassium dihomoallylic alkoxide under mild thermolytic conditions.
