1023289-64-6Relevant articles and documents
Preparation method 3 -aldehyde -5 -methylbenzoic acid
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Paragraph 0018-0019; 0023-0024; 0028-0029, (2020/08/14)
The invention belongs to the technical field of organic synthesis, and particularly relates to a preparing method of 3-formyl group-5-methylbenzoid acid. According to the preparing method, 3-bromine-5-methylbenzaldehyde serves as a raw material, 3-bromine-5-methylbenzaldehyde reacts with alcohol to prepare acetal, acetal is subjected to a lithium-halogen exchanging reaction with a lithiation reagent to prepare a phenyl lithium compound, the phenyl lithium compound is reacted with carbon dioxide, then 3-formyl group-5-methylbenzoid acid is obtained through decomposition of diluted hydrochloricacid, finally through purification, 3-formyl group-5-methyl benzoic acid is obtained, and the reacted solvent is tetrahydrofuran. The preparing method of 3-formmyl group-5-methylbenzoid acid has the advantages that raw materials are cheap and easy to obtain, the reaction condition is mild, the aftertreatment operation is simple, the production cost is low, the reaction cost is lowered, and the preparing method is suitable for industrialized production.
PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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Page/Page column 80, (2010/04/03)
The present invention relates to 2-pyridone derivatives of Formula (I) or (IV) as herein described, compositions containing such compounds, synthetic processes for making such compounds, and therapeutic methods that include the administration of such comp
