4481-27-0

Basic information

• Product Name: 3-Formyl-5-methylbenzoic acid
• Synonyms: 3-Formyl-5-methylbenzoic acid
• CAS NO: 4481-27-0
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.15802
• Mol File: 4481-27-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-Formyl-5-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Formyl-5-methylbenzoic acid(4481-27-0)
• EPA Substance Registry System: 3-Formyl-5-methylbenzoic acid(4481-27-0)

Safety Data

• Hazardous Substances Data: 4481-27-0(Hazardous Substances Data)

Upstream product

• 1023289-64-6 2-(3-bromo-5-methylphenyl)-1,3-dioxolane 
• 124-38-9 carbon dioxide 
• 550367-75-4 3-bromomethyl-5-methylbenzoic acid 
• 63440-59-5 3-hydroxymethyl-5-methylbenzoic acid 
• 499-06-9 3,5-dimethylbenzoic acid 
• 52107-90-1 3-iodo-5-methylbenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1187028-47-2 3-[(ethyl-methyl-amino)-methyl]-5-methyl-benzoic acid 
• 1187028-49-4 3-[3-(3-ethyl-4-hydroxy-5-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-5-methyl-benzaldehyde 
• 1187028-76-7 (S)-N-(3-(4-(5-(3-((dimethylamino)methyl)-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 
• 1187028-77-8 (S)-N-(3-(2-ethyl-4-(5-(3-((ethyl(methyl)amino)methyl)-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 
• 1187028-78-9 (S)-N-(3-(2-ethyl-6-methyl-4-(5-(3-methyl-5-((methyl(propyl)amino)methyl)phenyl)-1,2,4-oxadiazol-3-yl)phenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 
• 1187028-79-0 (S)-N-(3-(4-(5-(3-((butyl(methyl)amino)methyl)-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 
• 1187028-75-6 (S)-N-(3-(2-ethyl-4-(5-(3-((isobutylamino)methyl)-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 
• 1187028-80-3 (S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 
• 1187028-48-3 3-[(ethyl-methyl-amino)-methyl]-5-methyl-benzoic acid hydrazide 
• 1187029-85-1 2-ethyl-4-(5-{3-[(ethyl-methyl-amino)-methyl]-5-methyl-phenyl}-[1,3,4]oxadiazol-2-yl)-6-methyl-phenol 
• 1187029-86-2 {3-[5-(4-benzyloxy-3-ethyl-5-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-5-methyl-benzyl}-ethyl-methyl-amine 

Relevant articles and documents

Preparation method 3 -aldehyde -5 -methylbenzoic acid

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparing method of 3-formyl group-5-methylbenzoid acid. According to the preparing method, 3-bromine-5-methylbenzaldehyde serves as a raw material, 3-bromine-5-methylbenzaldehyde reacts with alcohol to prepare acetal, acetal is subjected to a lithium-halogen exchanging reaction with a lithiation reagent to prepare a phenyl lithium compound, the phenyl lithium compound is reacted with carbon dioxide, then 3-formyl group-5-methylbenzoid acid is obtained through decomposition of diluted hydrochloricacid, finally through purification, 3-formyl group-5-methyl benzoic acid is obtained, and the reacted solvent is tetrahydrofuran. The preparing method of 3-formmyl group-5-methylbenzoid acid has the advantages that raw materials are cheap and easy to obtain, the reaction condition is mild, the aftertreatment operation is simple, the production cost is low, the reaction cost is lowered, and the preparing method is suitable for industrialized production.

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Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo.

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