1023301-87-2Relevant academic research and scientific papers
Total synthesis and cytotoxicity of haterumalides NA and B and their artificial analogues
Ueda, Mitsuru,Yamaura, Masashi,Ikeda, Yoichi,Suzuki, Yuta,Yoshizato, Kensaku,Hayakawa, Ichiro,Kigoshi, Hideo
supporting information; experimental part, p. 3370 - 3377 (2009/09/30)
The total synthesis of haterumalides NA and B, potent cytotoxic marine macrolides, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps. Compared to our first-generation approach for enf-haterumalide NA methy
Total synthesis of haterumalides NA and NC via a chromium-mediated macrocyclization
Schomaker, Jennifer M.,Borhan, Babak
scheme or table, p. 12228 - 12229 (2009/02/05)
The syntheses of haterumalides NA and NC were accomplished via the macrocyclization of a chlorovinylidene chromium carbenoid onto a pendant aldehyde to generate the C8-C9 bond with the desired stereoisomer as the major product. Utilizing the latter chemistry enables access to both C9 hydroxylated (haterumalides NC and ND) and C9 deoxygenated forms (haterumalides NA, NB, and NE; via deoxygenation of the C9-hydroxyl). Copyright
