1023327-73-2Relevant academic research and scientific papers
Synthesis and structure-activity relationship studies of cytotoxic cinnamic alcohol derivatives
Zou, Hong-Bin,Zhang, Liang,Yang, Lei-Xiang,Yang, Liu-Qing,Zhao, Yu,Yu, Yong-Ping,Stoeckigt, Joachim
, p. 203 - 221 (2011/04/15)
Three series of di- and trisubstituted derivatives of cinnamic alcohol and its conjugated dienol analogues were designed and synthesised. The derivatives were screened for cytotoxicity against nine tumour cell lines: KB, A549, Hela, CNE, PC-3, BEL-7404, HL-60, BGC823 and P388D1. Most of the cinnamic alcohol derivatives showed cytotoxic activity. The compound 7-(4',5'-dichlorobenzyloxy)- 6,8-dihydroxycinnamic alcohol (55) exhibited significant cytotoxicity to seven human tumour cell lines on a micromolar range, especially with regard to the KB and P388D1 cell lines, showing IC50 values of 0.4 and 0.5μ M, respectively. The structure-activity relationships of the derivatives are discussed.
