33398-36-6

Upstream product

• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 603-35-0 triphenylphosphine 

Downstream Products

• 101619-71-0 (2E,4E)-ethyl 5-(3,4-dimethoxyphenyl)penta-2,4-dienoate 
• 151720-79-5 (2E,4E)-5-(4-Benzenesulfonylamino-phenyl)-penta-2,4-dienoic acid ethyl ester 
• 151720-62-6 (2E,4E)-5-(2-Benzenesulfonylamino-phenyl)-penta-2,4-dienoic acid ethyl ester 
• 151720-75-1 (2E,4E)-5-(3-Benzenesulfonylamino-phenyl)-penta-2,4-dienoic acid ethyl ester 
• 151720-93-3 (2E,4E)-5-(3-Benzenesulfonylamino-naphthalen-2-yl)-penta-2,4-dienoic acid ethyl ester 
• 916059-55-7 (2E,4Z)-5-(3-methanesulfonylaminophenyl)pentadienoic acid ethyl ester 
• 916059-56-8 (2E,4E)-5-(3-methanesulfonylaminophenyl)pentadienoic acid ethyl ester 
• 1055325-76-2 6-(3,4-dimethoxyphenyl)-4-(4-fluoro-phenyl)-cyclohexa-1,3-dienecarboxylic acid ethyl ester 
• 1023327-73-2 (2Z,4Z)-5-[3',5'-dimethoxy-4'-(4''-ethoxybenzyloxy)phenyl]-2,4-pentadienoic acid ethyl ester 
• 1023327-71-0 (2E,4E)-5-[3',5'-dimethoxy-4'-(4''-ethoxybenzyloxy)phenyl]-2,4-pentadienoic acid ethyl ester 
• 791-28-6 Triphenylphosphine oxide 
• 77085-08-6 C₄₈H₄₈O₄P₂⁽²⁺⁾*2Br^(1-) 
• 77085-13-3 ((3E,5E)-3-Ethoxycarbonyl-2-ethoxycarbonylmethyl-6-phenyl-hexa-3,5-dienyl)-triphenyl-phosphonium; bromide 
• 77085-10-0 ((E)-3-Ethoxycarbonyl-2-ethoxycarbonylmethyl-pent-3-enyl)-triphenyl-phosphonium; bromide 

Relevant academic research and scientific papers

An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir

A novel synthetic route towards oseltamivir, an influenza neuraminidase inhibitor, has been achieved employing a cationic iron carbonyl complex, providing an alternate pathway with the potential to access diverse analogues. The Royal Society of Chemistry.

Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720

FTY720 (1) is a novel immunosuppressant (immunomodulator), derived from ISP-I (2: myriocin and thermozymocidin). To clarify the pharmacokinetic properties of 1, antibodies against 1 were prepared and a competitive enzyme immunoassay (EIA) was developed. T

Conformational analogues of Oxamflatin as histone deacetylase inhibitors

Conformational analogues of the hydroxamic acid Oxamflatin 1 - compounds 3a, 3b and 4 - have been synthesised to enable evaluation of the impact of varying the linking section on histone deacetylase inhibition. Preliminary testing indicates treatment of l

Synthesis of Alkylphenols and -catechols from Plectranthus albidus (Labiatae)

In the preceding paper, we described the isolation and structure elucidation of a series of even-numbered phenol- or pyrocatechol-derived 1-arylalkane-5-ones.To establish the assigned structures unambiguously and to have larger quantities available for physiological testing, the following compounds were prepared: in the alkylphenol series, 1-(4'-hydroxyphenyl)tetradecan-5-one (2a), 1-(4'-hydroxyphenyl)hexadecan-5-one (2b), and 1-(4'-hydroxyphenyl)octadecan-5-one (2c); in the alkylcatechol series, 1-(3',4'-dihydroxyphenyl)decan-5-one (3a; not isolated as a natural compound), 1-(3',4'-dihydroxyphenyl)dodecan-5-one (3b), 1-(3',4'-dihydroxyphenyl)tetradecan-5-one (3c), 1-(3',4'-dihydroxyphenyl)hexadecan-5-one (3d), 1-(3',4'-dihydroxyphenyl)octadecan-5-one (3e), and 1-(3',4'-dihydroxyphenyl)icosan-5-one (3f); in the alkenylphenol series, (Z)-1-(4'-hydroxyphenyl)octadec-13-en-5-one (4a) and (E)-1-(4'-hydroxyphenyl)octadec-13-en-5-one (4b); in the alkenylcatechol series, (E,E)-1-(3',4'-dihydroxyphenyl)deca-1,3-dien-5-one (1) and (Z)-1-(3',4'-dihydroxyphenyl)octadec-13-en-5-one (5).All compounds proved to be identical with the previously assigned structures.Compound 1 was synthesized by regioselective aldol condensation of heptan-2-one with (E)-3-(3',4'-dimethoxyphenyl)prop-2-enal (6d; Scheme 1), the phenols 2a-c and the catechols 3a-f by addition of the corresponding alkyl Grignard reagent to 5-(4'-methoxyphenyl)- or 5-(3',4'-dimethoxyphenyl)pentanal (17c and 18c, resp.; Scheme 4), and the olefins 4a, 4b and 5 from 17c or 18c via the 9-O-silyl-protected 13-(4'-methoxyphenyl)- or 13-(3',4'-dimethoxyphenyl)tridecanals (26 and 27, resp.) and Wittig olefination as the key steps (Scheme 5).