102333-75-5

Usage

General Description

2-amino-2-(4-chlorophenyl)acetamide is a chemical compound with the molecular formula C8H9ClN2O. It is a derivative of acetamide and contains a chlorine-substituted phenyl ring. 2-amino-2-(4-chlorophenyl)acetamide is commonly used in the synthesis of pharmaceuticals, particularly as a building block for the production of various drugs. It has also been studied for its potential use as an anticonvulsant and neuroprotective agent. Additionally, it has shown potential as a biochemical tool in the study of various biological processes. The compound is considered to be of moderate toxicity and should be handled with care in laboratory settings.

Upstream product

• 56464-72-3 2-amino-2-(p-chlorophenyl)acetonitrile 
• 102604-22-8 C₁₃H₁₂ClNOS 
• 42718-19-4 dl-α-4-chlorophenylglycine methyl ester hydrochloride 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 773837-37-9 sodium cyanide 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 67336-19-0 (S)-2-amino-2-(4-chlorophenyl)acetic acid 
• 43189-37-3 (R)-2-amino-2-(4-chlorophenyl)acetic acid 
• 92303-74-7 4-chloro-(RS)-phenylglycinamide hydrochloride 
• 923975-81-9 3-(4-chlorophenyl)-1,4-diazaspiro[4.5]dec-3-en-2-one 
• 923975-86-4 [3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetyl chloride 
• 923975-85-3 [3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetic acid 
• 923975-84-2 ethyl [3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetate 
• 1143532-81-3 4-amino-N-[2-amino-1-(4-chlorophenyl)2-oxoethyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 
• 1108685-96-6 L-2-(4-chloro-phenyl)-2-(2-methoxy-acetylamino)-acetamide 
• 1044506-90-2 3-(4-chlorophenyl)-8-oxa-1,4-diazaspiro[4.5]decan-2-one 
• 1044147-59-2 1,1-dimethylethyl 2-(4-chlorophenyl)-3-oxo-1,4,8-triazaspiro[4.5]decane-8-carboxylate 
• 65254-80-0 N-[Carbamoyl-(4-chloro-phenyl)-methyl]-2-mercapto-propionamide 

Relevant academic research and scientific papers

Enzymatic synthesis of chiral phenylalanine derivatives by a dynamic kinetic resolution of corresponding amide and nitrile substrates with a multi-enzyme system

Mutant α-amino-ε-caprolactam (ACL) racemase (L19V/L78T) from Achromobacter obae with improved substrate specificity toward phenylalaninamide was obtained by directed evolution. The mutant ACL racemase and thermostable mutant D-amino acid amidase (DaaA) from Ochrobactrum anthropi SV3 co-expressed in Escherichia coli (pACLmut/pDBFB40) were utilized for synthesis of (R)-phenylalanine and non-natural (R)-phenylalanine derivatives (4-OH, 4-F, 3-F, and 2-F-Phe) by dynamic kinetic resolution (DKR). Recombinant E. coli with DaaA and mutant ACL racemase genes catalyzed the synthesis of (R)-phenylalanine with 84% yield and 99% ee from (RS)-phenylalaninamide (400 mM) in 22 h. (R)-Tyrosine and 4-fluoro-(R)-phenylalanine were also efficiently synthesized from the corresponding amide compounds. We also co-expresed two genes encoding mutant ACL racemase and L-amino acid amidase from Brevundimonas diminuta in E. coli and performed the efficient production of various (S)-phenylalanine derivatives. Moreover, 2-aminophenylpropionitrile was converted to (R)-phenylalanine by DKR using a combination of the non-stereoselective nitrile hydratase from recombinamt E. coli and mutant ACL racemase and DaaA from E. coli encoding mutant ACL racemase and DaaA genes. Copyright

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of Formula (I) or a salt thereof are provided: wherein R6, R7, R8, R9, X, Ar, n, and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of formula (I) or a salt thereof are provided: wherein R6, R7, R9, R10, R11, X, n, p, Ar and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of formula (I) or a salt thereof are provided wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, X, n, p and m are as defined in the description. Uses o

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of formula (I) or a salt thereof are provided wherein R1, R2, R6, R7, R8, R9 and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture

Glyt1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders

The invention provides a compound of formula (I) or a solvate thereof: wherein R1, R2, R3, R4, R5, R6, and n are as defined in the specification, and uses of such compounds. The compounds i

N-PHENYL-2-0X0-1,4-DIAZASPIR0 [4.5] DEC-3-EN-1-YL ACETAMIDE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS

Compounds of formula (I) and salts and solvates are provided: Formula (I) Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention d

1-(2-ARYL-2-OXOETHYL)-3-PHENYL-1, 4-DIAZASPIRO [4.5]DEC-3-EN-2-ONE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS

Novel acetophenone compounds of formula (I), compositions containing (I), processes for the preparation of (I), and use of (I) as inhibitors of the glycine transporter, are provided. Definitions of Ar, R5, R6, R7, R8

ETUDE DE LA RECTIVITE D'YLURES DE SULFONIUM ET DE PYRIDINIUM STABILISES PAR UN GROUPEMENT CYANOFORMYLE.

The sulfonium and pyridinium ylides stabilized by a cyanoformyl group, in acidic medium, lead to sulfonium and pyridinium ketene salts.This originality has been used to prepare new stabilized ylides, or derivatives of substituted arylacetic acids or 4-hydroxy thiazoles.