1023334-50-0Relevant articles and documents
Derivative containing 1, 2, 4-mercaptotriazole and preparation method and application of derivative
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Paragraph 0140-0141, (2020/11/26)
The invention relates to the technical field of medicinal chemistry, in particular to a derivative containing 1, 2, 4-mercaptotriazole and a preparation method and application of the derivative. The derivative containing 1, 2, 4-mercaptotriazole has relatively good inhibitory activity on DCN1-UBC12 protein-protein interaction, so that the 1, 2, 4-mercaptotriazole derivative has relatively good inhibitory activity on DCN1-UBC12 protein-protein interaction. According to the record of the embodiment, compared with NAcM-COV, the derivative containing 1, 2, 4-mercaptotriazole provided by the invention has better inhibitory activity on DCN1-UBC12 protein-protein interaction, and the structural formula of the derivative containing 1, 2, 4-mercaptotriazole is shown in the specification.
BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS
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Page/Page column 31, (2019/02/06)
Provided are SUMO activators, which can enhance SUMOylation of SERCA2a, which are useful in the treatment of heart failure, cardiovascular diseases, cancer, neurodegenerative disorders, viral infection, bacterial infection, liver disease, inflammation, and other diseases.
SUBSTITUTED OXOPYRIDINE DERIVATIVES
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Page/Page column 83-84, (2017/02/09)
The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and o edemas, and also ophthalmic disorders.