936-08-3

Basic information

• Product Name: 2-Bromo-4-chlorobenzoic acid
• Synonyms: Benzoic acid, 2-bromo-4-chloro-;2-BROMO-4-CHLOROBENZOIC ACID;2-BroM-4-chlorobenzoic acid;2-BroMo-4-chlorobenz
• CAS NO: 936-08-3
• Molecular Formula: C₇H₄BrClO₂
• Molecular Weight: 235.46
• Product Categories: blocks;Bromides;Carboxes;Benzoic acid;Acids & Esters;Bromine Compounds;Chlorine Compounds;C7;Carbonyl Compounds;Carboxylic Acids;Benzoic acid series;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;intermediate
• Mol File: 936-08-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 159 °C
• Boiling Point: 326.5 °C at 760 mmHg
• Flash Point: 151.3 °C
• Appearance: /Solid
• Density: 1.809 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.62±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-4-chlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-chlorobenzoic acid(936-08-3)
• EPA Substance Registry System: 2-Bromo-4-chlorobenzoic acid(936-08-3)

Safety Data

• Hazard Codes: Xi,N,C,Xn
• Statements: 36/37/38-50-34-22
• Safety Statements: 26-36/37/39-61-45
• RIDADR: UN 2928
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 936-08-3(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

Upstream product

• 7745-87-1 3-bromo-4-methyl-aniline; hydrochloride 
• 119-32-4 4-Methyl-3-nitroanilin 
• 95-46-5 2-methylphenyl bromide 
• 106-43-4 para-chlorotoluene 
• 6833-15-4 4-chlorobenzanilide 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 27139-97-5 2-bromo-4-chloro-1-methyl-benzene 

Downstream Products

• 141829-05-2 2-(2-Carboxy-5-chloro-phenyl)-malonic acid dimethyl ester 
• 1221746-46-8 2-((2-carboxy-4-chlorophenyl)amino)-3-methoxybenzoic acid 
• 1127896-91-6 (Z)-2-benzyl-5-chloro-3-(phenylmethylene)isoindolin-1-one 
• 1127896-50-7 N-benzyl 2-bromo-4-chlorobenzamide 
• 947263-29-8 2-cyano-4-chloro-4'-fluorobenzophenone 
• 947263-30-1 2-(4-fluorobenzoyl)-4-chlorobenzoic acid 
• 947263-33-4 methyl 2-(4-fluorobenzoyl)-4-chlorobenzoate 
• 98242-53-6 1-(4-chloro-2-hydroxymethylphenyl)-1-(4-fluorophenyl)methanol 
• 947263-32-3 1-(4-fluorophenyl)-1,3-dihydro-5-chloro-isobenzofuran 
• 64169-67-1 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile 
• 59729-33-8 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile 
• 63177-08-2 4-chloro-2-(carboxymethyl)benzoic acid 

Relevant articles and documents

The synthesis and electronic absorption spectra of 3-phenyl-3(4- pyrrolidino-2-substituted phenyl)-3H-naphtho[2,1-b]pyrans: Further exploration of the ortho substituent effect

Introduction of a substituent into a sterically demanding 2-position of a 3-(4-pyrrolidinophenyl) ring of a 3,3-diaryl-3H-naphtho[2,1-b]pyran results in the generation of an additional short wavelength absorption band leading to organic photochromes that

Application of Organolithium and Related Reagents in Synthesis XVI: Synthetic Strategies Based on Aromatic Metallation. A Concise Regiospecific Conversion of Chlorobenzoic Acids into their Benzylated Derivatives

The reaction of benzyl bromide with bis-(N- and C-ortho)-lithiated chloroanilides 4, 5, and 6 has been examined.It has been found that in the case where the lithiated compound was derived from meta-methoxyanilides, pre-addition of LiBr or TMEDA was required to achieve C-benzylation.These results were accounted for by the conversion of the usually formed dimer into a mixed dimer with the LiBr or TMEDA complex in which the C-lithium bond appears to be more accessible towards electrophiles.The practical synthesis of o-benzylchlorobenzoic acids 10, 11, and 12 was accomplished via ionic reductive cleavage (Et3SiH/TiCl4) of the corresponding phthalides 18, 19, and 20.The acids 10, 11b, and 11c afforded the corresponding anthrones, upon treatment with trifluoroacetic anhydride which were oxidized by chromium trioxide to the new chloroantraquinones 21, 22, and 23. - Keywords: Chlorophthalides; Reduction; Benzylation; Benzylbenzoic acids; Chloroantraquinones