1023339-58-3Relevant academic research and scientific papers
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates
Topalis, Dimitri,Pradère, Ugo,Roy, Vincent,Caillat, Christophe,Azzouzi, Ahmed,Broggi, Julie,Snoeck, Robert,Andrei, Graciela,Lin, Jay,Eriksson, Staffan,Alexandre, Julie A. C.,El-Amri, Chahrazade,Deville-Bonne, Dominique,Meyer, Philippe,Balzarini, Jan,Agrofoglio, Luigi A.
scheme or table, p. 222 - 232 (2011/03/22)
Acyclic nucleoside phosphonates (ANPs) are at the cornerstone of DNA virus and retrovirus therapies. They reach their target, the viral DNA polymerase, after two phosphorylation steps catalyzed by cellular kinases. New pyrimidine ANPs have been synthesize
Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
Kumamoto, Hiroki,Topalis, Dimitri,Broggi, Julie,Pradère, Ugo,Roy, Vincent,Berteina-Raboin, Sabine,Nolan, Steven P.,Deville-Bonne, Dominique,Andrei, Graciela,Snoeck, Robert,Garin, Daniel,Crance, Jean-Marc,Agrofoglio, Luigi A.
, p. 3517 - 3526 (2008/09/21)
In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step. Modification at the C-5 position of the uracil moiety was performed under optimized Pd(0)-catalyzed Stille cross-coupling conditions. None of the obtained compounds were active against poxviruses, nor do they exhibit any toxicity.
