102389-96-8

Upstream product

• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 

Downstream Products

• 1053246-05-1 2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethanol 
• 1632157-52-8 1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)propan-2-one 
• 1632157-34-6 C₂₅H₃₄O₅ 
• 1632157-38-0 C₂₃H₂₈O₅ 
• 1632157-24-4 C₂₃H₂₈O₅ 
• 1632157-44-8 C₂₇H₃₆O₅ 
• 1632157-30-2 C₂₇H₃₆O₅ 
• 1632157-46-0 C₂₇H₂₉FO₅ 
• 1632157-32-4 C₂₇H₂₉FO₅ 
• 1022915-06-5 2-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-1-phenylethanone 
• 1632157-22-2 (R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol 
• 1632157-54-0 (R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol 
• 1632157-53-9 (S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol 
• 1632157-36-8 C₂₂H₂₈O₅ 

Relevant academic research and scientific papers

A chiral benzyl group as a chiral auxiliary and protecting group for the synthesis of optically active 1,2-Diols and (+)-Frontalin

Chelation-controlled asymmetric nucleophilic addition of a Grignard reagent to chiral α-benzyloxy ketones gives the corresponding alcohols with high diastereoselectivities (up to 96% de) by 1,4-asymmetric induction. A chiral benzyl group is used as a chiral auxiliary as well as a protecting group for the synthesis of optically active 1,2-diols and (+)-frontalin. Georg Thieme Verlag Stuttgart, New York.

A novel stereoselective total synthesis of (+)-5-epi-cytoxazone

Stereoselective synthesis of a potent cytokine modulator cytoxazone isomer has been achieved from 2,3-O-isopropylidene D-glyceraldehyde involving Grignard reaction, subsequent formation of an azide followed by reduction to the aminodiol, and finally cyclization of the N-Boc diol. Copyright

Bidentate chelation-controlled asymmetric synthesis of α-hydroxy esters based on the glycolate enolate alkylation

(S)-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl](4-methoxyphenyl)methanol (4b) has been synthesized and evaluated as a chiral auxiliary for the asymmetric synthesis of α-hydroxy esters based on bidentate chelation-controlled alkylation of glycolate enolate. (C) 2000 Elsevier Science Ltd.

Stereoselectivity syn-Reduction of (R)-4-Acyl-2,2-dimethyl-1,3-dioxolanes with Metal Hydride Reagents

Lithium tri-s-butylborohydride and lithium aluminum hydride were found to be efficient reducing agents for the stereoselective preparation of syn-glycerol derivatives from (R)-4-acyl-2,2-dimethyl-1,3-dioxolanes.The scope and limitation of the stereoselect

Synthesis of the rarely obtained syn-Adducts in the Reaction of Organocopper Compounds with 2,3-O-Isopropylideneglyceraldehyde. Preparation of Optically Active Epoxy Alcohols

Organocopper compounds, prepared from Grignard reagents and copper(I) iodide in tetrahydrofuran-dimethyl sulphide, react with 2,3-O-isopropylideneglyceraldehyde highly stereoselectively (>10:1) affording the rarely obtained syn-addition products which can be readily converted into optically active epoxy alcohols, useful intermediates in organic synthesis.