1632157-22-2

Upstream product

• 102389-96-8 (2R,3R)-3-hydroxy-1,2-O-isopropylidene-3-p-methoxyphenyl-1,2-propanediol 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 1632157-52-8 1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)propan-2-one 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 1632157-51-7 (R)-4-((R)-(4-methoxyphenyl)((2-methylallyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolane 
• 1022915-06-5 2-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-1-phenylethanone 
• 676-58-4 methylmagnesium chloride 
• 1022915-05-4 (R)-4-((R)-(4-methoxyphenyl)((2-phenylallyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolane 

Downstream Products

• 2406-22-6 (R)-1-phenyl-1,2-ethanediol 

Relevant academic research and scientific papers

A chiral benzyl group as a chiral auxiliary and protecting group for the synthesis of optically active 1,2-Diols and (+)-Frontalin

Chelation-controlled asymmetric nucleophilic addition of a Grignard reagent to chiral α-benzyloxy ketones gives the corresponding alcohols with high diastereoselectivities (up to 96% de) by 1,4-asymmetric induction. A chiral benzyl group is used as a chiral auxiliary as well as a protecting group for the synthesis of optically active 1,2-diols and (+)-frontalin. Georg Thieme Verlag Stuttgart, New York.