1023970-85-5Relevant academic research and scientific papers
A portable albumin binder from a DNA-encoded chemical library
Dumelin, Christoph E.,Truessel, Sabrina,Buller, Fabian,Trachsel, Eveline,Bootz, Frank,Zhang, Yixin,Mannocci, Luca,Beck, Susanne C.,Drumea-Mirancea, Mihaela,Seeliger, Mathias W.,Baltes, Christof,Mueggler, Thomas,Kranz, Felicitas,Rudin, Markus,Melkko, Samu,Scheuermann, Joerg,Neri, Dario
, p. 3196 - 3201 (2008)
(Figure Presented) Seeing eye to eye: Plasma-protein binding is effective in improving the pharmacokinetic properties of otherwise short-lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half-life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture).
