Angewandte Chemie - International Edition p. 3196 - 3201 (2008)
Update date:2022-08-05
Topics:
Dumelin, Christoph E.
Truessel, Sabrina
Buller, Fabian
Trachsel, Eveline
Bootz, Frank
Zhang, Yixin
Mannocci, Luca
Beck, Susanne C.
Drumea-Mirancea, Mihaela
Seeliger, Mathias W.
Baltes, Christof
Mueggler, Thomas
Kranz, Felicitas
Rudin, Markus
Melkko, Samu
Scheuermann, Joerg
Neri, Dario
(Figure Presented) Seeing eye to eye: Plasma-protein binding is effective in improving the pharmacokinetic properties of otherwise short-lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half-life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture).
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Doi:10.1021/jacs.8b01618
(2018)Doi:10.1016/j.bmc.2007.11.052
(2008)Doi:10.1016/j.tet.2008.01.102
(2008)Doi:10.1007/s00044-007-9031-x
(2007)Doi:10.1016/j.jorganchem.2008.01.017
(2008)Doi:10.1002/anie.200704360
(2008)
