1023971-97-2Relevant academic research and scientific papers
Mild electrophilic trifluoromethylation of secondary and primary aryl- and alkylphosphines using hypervalent iodine(III)-CF3 reagents
Eisenberger, Patrick,Kieltsch, Iris,Armanino, Nicolas,Togni, Antonio
, p. 1575 - 1577 (2008/12/21)
A direct, mild and efficient trifluoromethylation of primary and secondary phosphines is achieved with easily accessible, cheap hypervalent iodine compounds acting as electrophilic CF3-transfer reagents. The Royal Society of Chemistry.
Recent advances in electrophilic CF3-transfer using hypervalent iodine(III) reagents
Kieltsch, Iris,Eisenberger, Patrick,Stanek, Kyrill,Togni, Antonio
scheme or table, p. 260 - 263 (2009/04/07)
The development of new methodologies for an efficient introduction of CF3 groups into complex molecules constitutes one of the most challenging tasks of modern organic chemistry. Recently, we reported the access to a new class of electrophilic CF3-transfer reagents based on hypervalent iodine. The versatile application of these reagents to C-centred nucleophiles, such as β-keto esters, silyl enol ethers and α-nitro esters, as well as to thiols and primary and secondary phosphines is described. Experiments with phenols afforded corresponding trifluomethylethers in very low yields. Schweizerische Chemische Gesellschaft.
