1024036-96-1

Basic information

• Product Name: methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate
• Synonyms: methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate
• CAS NO: 1024036-96-1
• Molecular Weight: 433.615
• Mol File: 1024036-96-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate(1024036-96-1)
• EPA Substance Registry System: methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate(1024036-96-1)

Safety Data

• Hazardous Substances Data: 1024036-96-1(Hazardous Substances Data)

Upstream product

• 58584-83-1 2,6-dichloronicotinoyl chloride 
• 1003872-51-2 2,6-dichloro-N-cyclohexyl-pyridine-3-carboxamide 
• 865157-03-5 methyl-(R)-3-piperidine acetate hydrochloride 
• 1024036-99-4 6-chloro-N-cyclohexyl-2-propylsulfanylpyridine-3-carboxamide 

Downstream Products

• 1024037-59-9 methyl 2-[(3R)-1-[5-(cyclohexyl-methyl-carbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate 
• 1024033-31-5 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid 

Relevant articles and documents

Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: Discovery of 2-[(3 s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]- 3-piperidyl]acetic acid (AZD4017)

Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. We report here the discovery of a nicotinic amide derived carboxylic acid class of inhibitors that has good potency, selectivity, and pharmacokinetic characteristics. Compound 11i (AZD4017) is an effective inhibitor of 11β-HSD1 in human adipocytes and exhibits good druglike properties and as a consequence was selected for clinical development.