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102419-91-0

(R)-N-Deacetyl Colchicine is a bioactive compound derived from the plant Colchicum autumnale, commonly known as the autumn crocus. It is a structural analog of the natural product colchicine and exhibits antimitotic properties. The compound is characterized by its ability to bind to tubulin, a protein component of microtubules, and inhibit its polymerization, thereby disrupting the normal function of these cellular structures.

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  • 102419-91-0 Structure

  • Basic information

    1. Product Name: (R)-N-Deacetyl Colchicine
    2. Synonyms: (7R)-7-AMino-6,7-dihydro-1,2,3,10-tetraMethoxy-benzo[a]heptalen-9(5H)-one;(R)-N-Deacetyl Colchicine
    3. CAS NO:102419-91-0
    4. Molecular Formula: C20H23NO5
    5. Molecular Weight: 357.40032
    6. EINECS: N/A
    7. Product Categories: Amines;Chiral Reagents;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Chiral Reagents, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 102419-91-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-N-Deacetyl Colchicine(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-N-Deacetyl Colchicine(102419-91-0)
    11. EPA Substance Registry System: (R)-N-Deacetyl Colchicine(102419-91-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 102419-91-0(Hazardous Substances Data)

102419-91-0 Usage

Uses

Used in Pharmaceutical Industry:
(R)-N-Deacetyl Colchicine is used as an antimitotic agent for its ability to disrupt microtubules by binding to tubulin and preventing its polymerization. This action leads to the stimulation of the intrinsic GTPase activity of tubulin, which in turn induces apoptosis in several normal and tumor cell lines. Additionally, it activates the JNK/SAPK signaling pathway, which plays a role in the regulation of cell growth and apoptosis.
Used in Cancer Treatment:
(R)-N-Deacetyl Colchicine is employed in the treatment of various types of cancer due to its antimitotic and apoptotic effects. Its ability to disrupt microtubules and induce apoptosis makes it a valuable compound in the development of cancer therapeutics. The compound's mode of action also suggests potential synergistic effects when combined with other chemotherapeutic agents, which could enhance the overall efficacy of cancer treatment regimens.

Check Digit Verification of cas no

The CAS Registry Mumber 102419-91-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,4,1 and 9 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 102419-91:
(8*1)+(7*0)+(6*2)+(5*4)+(4*1)+(3*9)+(2*9)+(1*1)=90
90 % 10 = 0
So 102419-91-0 is a valid CAS Registry Number.

102419-91-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (7R)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

1.2 Other means of identification

Product number -
Other names (R)-N-Deacetyl Colchicine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:102419-91-0 SDS

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