(R)-N-Deacetyl Colchicine

Base Information

Chemical Name:(R)-N-Deacetyl Colchicine
CAS No.:102419-91-0
Molecular Formula:C₂₀H₂₃NO₅
Molecular Weight:357.406
Hs Code.:
Mol file:102419-91-0.mol

Synonyms:(R)-N-Deacetyl Colchicine;(7R)-7-AMino-6,7-dihydro-1,2,3,10-tetraMethoxy-benzo[a]heptalen-9(5H)-one

Suppliers and Price of (R)-N-Deacetyl Colchicine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-N-DeacetylColchicine
2.5mg
$ 250.00

Biosynth Carbosynth
(7R)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
1 mg
$ 224.90

Biosynth Carbosynth
(7R)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
25 mg
$ 2457.00

Biosynth Carbosynth
(7R)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
10 mg
$ 1351.40

Biosynth Carbosynth
(7R)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
5 mg
$ 743.30

Biosynth Carbosynth
(7R)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
2 mg
$ 408.80

AK Scientific
(R)-N-DeacetylColchicine
1mg
$ 353.00

Total 2 raw suppliers

Chemical Property of (R)-N-Deacetyl Colchicine

Chemical Property:

PSA：80.01000
LogP:3.39450

Purity/Quality:

97% ^*data from raw suppliers

(R)-N-DeacetylColchicine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Technology Process of (R)-N-Deacetyl Colchicine

There total 5 articles about (R)-N-Deacetyl Colchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73307-44-5,68296-64-0
7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

: 102419-91-0
(+)-N-deacetylcolchicine

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / Na₂CO₃ / diethyl ether / 2.5 h / Ambient temperature

2: 46 percent / methanol; diethyl ether / 3 h

3: 70 percent / K₂CO₃ / acetone; H₂O / 60 °C

With sodium carbonate; potassium carbonate; In methanol; diethyl ether; water; acetone;
DOI:10.1021/jo00363a021

Reference yield:

: 209810-38-8,54192-66-4
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide

: 102419-91-0
(+)-N-deacetylcolchicine

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / 20percent H₂SO₄ / acetic acid / 5 h / 80 - 90 °C

2: 79 percent / Na₂CO₃ / diethyl ether / 2.5 h / Ambient temperature

3: 46 percent / methanol; diethyl ether / 3 h

4: 70 percent / K₂CO₃ / acetone; H₂O / 60 °C

With sulfuric acid; sodium carbonate; potassium carbonate; In methanol; diethyl ether; water; acetic acid; acetone;
DOI:10.1021/jo00363a021

Reference yield:

: 102491-70-3
(+/-)-N-(trifluoroacetyl)deacetylcolchiceine

: 102419-91-0
(+)-N-deacetylcolchicine

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / methanol; diethyl ether / 3 h

2: 70 percent / K₂CO₃ / acetone; H₂O / 60 °C

With potassium carbonate; In methanol; diethyl ether; water; acetone;
DOI:10.1021/jo00363a021