10242-00-9

Usage

Uses

Used in Pharmaceutical Industry:
6-NITRO-1H-INDOLE-2-CARBOXYLIC ACID is used as a key intermediate for the synthesis of oxazoles, triazoles, and related heterocycles. These heterocyclic compounds have been identified as mitochondrial activity inhibitors, which can be employed in the treatment of various types of cancers. By targeting mitochondrial activity, these compounds can disrupt cellular processes and inhibit tumor growth, making them valuable tools in the development of novel anticancer therapies.
In the preparation of these bioactive heterocycles, 6-NITRO-1H-INDOLE-2-CARBOXYLIC ACID serves as a versatile building block, allowing for the creation of a diverse range of compounds with potential therapeutic applications. Its use in the pharmaceutical industry is primarily focused on the development of new drugs for cancer treatment, leveraging its ability to form various heterocyclic structures with biological activity.

Upstream product

• 134747-25-4 ethyl 2-[2-(3-nitrophenyl)hydrazinylidene]propanoate 
• 4993-93-5 4-nitro-1H-indole-2-carboxylic acid ethyl ester 
• 99-09-2 3-nitro-aniline 
• 51516-96-2 3-nitrophenylhydrazine hydrochloride 
• 1056933-72-2 (E)-ethyl 2-(2-(3-nitrophenyl)hydrazono)propanoate 
• 16792-45-3 6-nitro-1H-indole-2-carboxylic acid ethyl ester 
• 136818-66-1 6-Nitro-1H-indole-2-carboxylic acid methyl ester 

Downstream Products

• 933474-57-8 C₂₁H₂₃N₃O 
• 120975-30-6 4-nitro-1H-indole-2-carbonitrile 
• 136818-66-1 6-Nitro-1H-indole-2-carboxylic acid methyl ester 
• 1093255-84-5 6-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate 
• 1093261-29-0 1,1-dimethylethyl (2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-6-yl)carbamate 
• 1093261-27-8 6-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1H-indole-2-carboxylic acid 
• 1093255-82-3 6-(acetylamino)-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide 

Relevant academic research and scientific papers

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Novel aromatic compounds possessing antifungal or antibacterial activity

The present invention provides novel compounds possessing antibacterial, antifungal, antiviral, anticancer, and/or antiparasitic activities. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds ar

Substituted indoles as anti-AIDS pharmaceuticals

Substituted indoles of formula (I) STR1 are useful anti-AIDS pharmaceuticals.

Anti-aids piperazines

The present invention includes diaromatic substituted heterocyclic compounds (III) STR1 which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).