10242-00-9

Basic information

• Product Name: 6-NITRO-1H-INDOLE-2-CARBOXYLIC ACID
• Synonyms: 6-NITRO-1H-INDOLE-2-CARBOXYLIC ACID;6-NITROINDOLE-2-CARBOXYLIC ACID;6-Nitroindol-2-carboxylic acid;6-Nitro-2-indolecarboxylic acid
• CAS NO: 10242-00-9
• Molecular Formula: C₉H₆N₂O₄
• Molecular Weight: 206.15
• Product Categories: Heterocycles
• Mol File: 10242-00-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 304-305℃
• Boiling Point: 520.8 °C at 760 mmHg
• Flash Point: 268.8 °C
• Appearance: /Solid
• Density: 1.632 g/cm³
• PKA: 4.03±0.30(Predicted)
• CAS DataBase Reference: 6-NITRO-1H-INDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-NITRO-1H-INDOLE-2-CARBOXYLIC ACID(10242-00-9)
• EPA Substance Registry System: 6-NITRO-1H-INDOLE-2-CARBOXYLIC ACID(10242-00-9)

Safety Data

• Hazardous Substances Data: 10242-00-9(Hazardous Substances Data)

Usage

Uses

6-Nitro-1H-indole-2-carboxylic Acid is used in preparation of oxazoles and triazoles and related heterocycles as mitochondrial activity inhibitors for treatment of cancers.

Upstream product

• 136818-66-1 6-Nitro-1H-indole-2-carboxylic acid methyl ester 
• 1056933-72-2 (E)-ethyl 2-(2-(3-nitrophenyl)hydrazono)propanoate 
• 134747-25-4 ethyl 2-[2-(3-nitrophenyl)hydrazinylidene]propanoate 
• 51516-96-2 3-nitrophenylhydrazine hydrochloride 
• 99-09-2 3-nitro-aniline 
• 4993-93-5 4-nitro-1H-indole-2-carboxylic acid ethyl ester 
• 16792-45-3 6-nitro-1H-indole-2-carboxylic acid ethyl ester 

Downstream Products

• 120975-30-6 4-nitro-1H-indole-2-carbonitrile 
• 136818-66-1 6-Nitro-1H-indole-2-carboxylic acid methyl ester 
• 1093255-84-5 6-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate 
• 1093261-29-0 1,1-dimethylethyl (2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-6-yl)carbamate 
• 1093261-27-8 6-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1H-indole-2-carboxylic acid 
• 1093255-82-3 6-(acetylamino)-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide 
• 1049677-82-8 1-(tert-butyl) 2-methyl 6-amino-1H-indole-1,2-dicarboxylate 
• 541522-65-0 methyl 6-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1H-indole-2-carboxylate 

Relevant articles and documents

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Novel aromatic compounds possessing antifungal or antibacterial activity

The present invention provides novel compounds possessing antibacterial, antifungal, antiviral, anticancer, and/or antiparasitic activities. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds ar