10242-13-4Relevant articles and documents
Novel intramolecular charge transfer effect-based ligands and aggregation-induced emission-active europium complexes: synthesis, characterization, and fluorescence properties
Yang, Shuaishuai,Guo, Zuping,Hu, Zhongqian,Guo, Dongcai
, p. 306 - 315 (2021)
Two novel coumarin derivatives and the corresponding europium complexes were prepared using a simple procedure. The pH response of the ligand and the aggregation-induced emission (AIE) properties of the target europium complex were studied. The ligand had an intramolecular charge transfer (ICT) effect and was linearly and sharply responsive under acidic conditions. The goal europium complexes exhibited excellent AIE performance when subjected to increasing concentrations of target europium complex or proportion of poor solvent. The effect of substituents on fluorescence strength or thermogravimetric and electrochemical properties was further investigated. The target complexes displayed the typical fluorescence of europium. The fluorescence amplitude of the target europium complexes was enhanced by the addition of electron-donating groups to ligands. Thermogravimetric research findings indicated that the target complexes possessed extreme thermal stability. Electrochemistry discovery findings indicated that the highest occupied molecular orbit energy level of EuL1 was greater than EuL2, but the lowest unoccupied molecular orbit energy level was smaller than that of EuL2. These complexes could be applied in medicinal chemistry, substance chemistry, and fluorescence labelling areas.
Novel coumarin-pyrazole carboxamide derivatives as potential topoisomerase II inhibitors: Design, synthesis and antibacterial activity
Liu, Hao,Ren, Zi-Li,Wang, Wei,Gong, Jie-Xiu,Chu, Ming-Jie,Ma, Quan-Wei,Wang, Jie-Chun,Lv, Xian-Hai
, p. 81 - 87 (2018)
The identification of novel Topoisomerase II (Topo II) inhibitors is one of the most attractive directions in the field of bactericide research and development. In our ongoing efforts to pursue the class of inhibitors, six series of 70 novel coumarin-pyrazole carboxamide derivatives were designed and synthesized. As a result of the evaluation against four destructive bacteria, including Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Salmonella. Compound 8III-k (MIC = 0.25 mg/L) showed considerable inhibitory activity than ciprofloxacin (MIC = 0.5 mg/L) against Escherichia coli and 8V-c (MIC = 0.05 mg/L) exhibited excellent antibacterial activity than ciprofloxacin (MIC = 0.25 mg/L) against Salmonella. The selected compounds (8III-k, 8V-c and 8V-k) exhibit potent inhibition against Topo II and Topo IV with IC50 values (9.4–25 mg/L). Molecular docking model showed that the compounds 8V-c and 8V-k can bind well to the target by interacting with amino acid residues. It will provide some valuable information for the commercial Topo II inhibiting bactericides.
Montmorillonite KSF as an inorganic, water stable, and reusable catalyst for the Knoevenagel synthesis of coumarin-3-carboxylic acids
Bigi, Franca,Chesini, Luca,Maggi, Raimondo,Sartori, Giovanni
, p. 1033 - 1035 (1999)
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NOVEL REACTIONS OF CARBON SUBOXIDE. IV. SYNTHESIS OF SOME N-HYDROXY-2-OXO-2H-1-BENZOPYRAN-3-CARBOXAMIDES
Bonsignore, Leonardo,Loy, Guiseppe,Secci, Mario
, p. 5013 - 5016 (1983)
Some N-hydroxy-2-oxo-2H-1-benzopyran-3-carboxamides have been prepared by reaction of carbon suboxide with 2-hydroxyaryloximes.
3 - Coumarin formic acid compound and application thereof as antibacterial agent for preparing plant pathogenic bacteria
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Paragraph 0039; 0044-0045; 0048-0049, (2021/03/24)
The invention relates to a compound with simple structure for inhibiting growth activity of phytopathogens, specifically relates to a 3-coumarin formic acid compound and application of the 3-coumarin formic acid compound as an antibacterial agent for preparing the phytopathogens, and discloses application of the 3-coumarin formic acid compound as the antibacterial agent for preparing the phytopathogens. The two 3-coumarin formic acid compounds has the following characteristics of molecular structure: the formulas are as shown in the specification, wherein R is hydrogen, methyl, methoxyl, hydroxyl, halogen and nitryl. The in vitro inhibitory activity of twenty-eight synthetic target compounds on four common plant pathogenic fungi such as apple decay pathogenic bacteria, apple ring spot pathogenic bacteria, maize curvularia pathogenic bacteria and potato dry rot pathogenic bacteria is measured by adopting a hypha linear growth rate method, so that the condition that all compounds have different inhibiting effects on supplied experimental bacteria is found.
Novel coumarin-thiazolyl ester derivatives as potential DNA gyrase Inhibitors: Design, synthesis, and antibacterial activity
Cheng, Xiang,Chu, Zhi-Wen,Hu, Rui,Liu, Hao,Lv, Xian-Hai,Xia, Dong-Guo
, (2020/05/14)
The design and synthesis of novel coumarin-thiazolyl ester derivatives of potent DNA gyrase inhibitory activity were the main aims of this study. All the novel synthesized compounds were examined for their antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Salmonella. Compound 8p exhibited excellent antibacterial activity against four bacteria strains with MIC values of 0.05, 0.05, 8, and 0.05 μg/mL, respectively. In vitro drug-resistant bacterial inhibition experiments indicated that compound 8p exhibited the best bacteriostatic effect in the selected compounds and four positive control drugs with MIC values of 4 μg/mL. In vitro enzyme inhibitory assay showed that compound 8p exhibited potent inhibition against DNA gyrase with IC50 values of 0.13 μM. The molecular docking model indicated that compounds 8p can bind well to the DNA gyrase by interacting with amino acid residues. This study demonstrated that the compound 8p can act as the most potent DNA gyrase inhibitor in the reported series of compounds and provide valuable information for the commercial DNA gyrase inhibiting bactericides.
