10242-20-3Relevant academic research and scientific papers
A regio- and diastereoselective platinum-catalyzed tandem [2+1]/[3+2] cycloaddition sequence
Achard, Thierry,Lepronier, Aymeric,Gimbert, Yves,Clavier, Herve,Giordano, Laurent,Tenaglia, Alphonse,Buono, Gerard
, p. 3552 - 3556 (2011)
Platinum complexes bearing phosphinous acids have efficiently promoted a tandem intermolecular sequence of [2+1]/[3+2] cycloaddition reactions. This process gave access to novel tricyclic systems and the cascade reactions were regio- and diastereoselective (see scheme; Cy=cyclohexyl). The [3+2] cycloaddition reaction was investigated further and two different alkyne partners were used. Copyright
Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H Insertion: Synthesis of Benzofused Six-Membered Azaheterocycles
Padín, Damián,Saá, Carlos,Varela, Jesús A.
supporting information, (2020/03/30)
The Cp*RuCl-based catalyst enables expedient access to a variety of benzofused six-membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild reaction conditions (room temperature, 15 min) and with excellent functional group tolerance. The synthetic utility of the final products and a mechanistic rationale are also discussed.
Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4- ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1
He, Junbo,Feng, Lingling,Li, Jing,Tao, Ruijuan,Wang, Fang,Liao, Xun,Sun, Qiushuang,Long, Qingwu,Ren, Yanliang,Wan, Jian,He, Hongwu
experimental part, p. 1665 - 1670 (2012/04/10)
As potential inhibitors of Escherichia coli pyruvate dehydrogenase complex E1 (PDHc E1), a series of novel 2-methylpyrimidine-4-ylamine derivatives were designed based on the structure of the active site of PDHc E1 and synthesized using 'click chemistry'.
A modular synthesis of alkynyl-phosphocholine headgroups for labeling sphingomyelin and phosphatidylcholine
Sandbhor, Mahendra S.,Key, Jessie A.,Strelkov, Ileana S.,Cairo, Christopher W.
supporting information; experimental part, p. 8669 - 8674 (2010/02/28)
(Figure Presented) A general route to phospho- and sphingolipids that incorporate an alkyne in the phosphocholine headgroup is described. The strategy preserves the ammonium functionality of the phosphocholine and can be easily modified to introduce desir
Novel exploration of the SNAr reaction
Raeppel, Stéphane,Raeppel, Franck,Suffert, Jean
, p. 794 - 796 (2007/10/03)
Propargylic, allylic and benzylic alcohols prove to be fairly successful as activated nucleophiles, under mild conditions for the SNAr reaction.
