102423-76-7

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 2700-22-3 Benzylidenemalononitrile 
• 93621-07-9 6-amino-4-phenyl-3,5-dicyano-3,4-dihydro-2(1H)-pyridinethione 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 40219-06-5 benzylidenecyanothioacetamide 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 135289-61-1 8-cyano-2-methyl 3-(p-nitrobenzylidene amino)-9-phenyl pyrido<3',2':4,5>thieno<3,2-d>pyrimidin-4,7-dione 
• 135289-49-5 (3,5-Dicyano-6-oxo-4-phenyl-1,6-dihydro-pyridin-2-ylsulfanyl)-acetic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 135289-46-2 N¹(3,5-dicyano-2-oxo-4-phenyl(1H)pyridin-6-ylthiomethyl carbonyl)-N⁴-phenylthiosemicarbazide 
• 135289-45-1 N¹(3,5-dicyano-2-oxo-4-phenyl(1H)pyridin-6-ylthiomethyl carbonyl)-N⁴-phenylsemicarbazide 
• 135289-55-3 3-Amino-5-cyano-6-oxo-4-phenyl-6,7-dihydro-thieno[2,3-b]pyridine-2-carboxylic acid (4-nitro-phenyl)-amide 
• 135289-56-4 2-carboethoxy-5-cyano 3-N,N-diacetylamino-4-phenylthieno<2,3-b>pyridin-6-(7H)-one 
• 135289-51-9 (3,5-Dicyano-6-oxo-4-phenyl-1,6-dihydro-pyridin-2-ylsulfanyl)-acetic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 135289-48-4 6(3',5'-dimethylpyrazol-1'-yl)carbonyl methyl thio 3,5-dicyano-4-phenylpyridin-2-(1H)-one 
• 135289-47-3 (3,5-Dicyano-6-oxo-4-phenyl-1,6-dihydro-pyridin-2-ylsulfanyl)-acetic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 135289-44-0 N-acetyl(3,5-dicyano-2-oxo-4-phenyl(1H)pyridin-6-ylthio)acetic acid hydrazide 
• 135289-68-8 3-Amino-5-cyano-6-oxo-4-phenyl-6,7-dihydro-thieno[2,3-b]pyridine-2-carboxylic acid pyridin-2-ylamide 
• 135289-53-1 3-Amino-5-cyano-6-oxo-4-phenyl-6,7-dihydro-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide 
• 135289-60-0 3-amino-8-cyano-2-methyl-9-phenyl-pyrido<3',2':4,5>thieno<3,2-d>pyrimidin-4,7-dione 
• 135289-70-2 3-Amino-2-(4-bromo-benzoyl)-6-oxo-4-phenyl-6,7-dihydro-thieno[2,3-b]pyridine-5-carbonitrile 

Relevant academic research and scientific papers

Activated Nitriles in Heterocyclic Synthesis: The Reaction of Cyanothioacetamide with Activated Double Bond Systems

Die Reaktion von Benzylidenmalononitrilen mit Cyanthioacetamid (1) ergibt je nach den Reaktionsbedingungen entweder Thiopyrane oder Pyridine.Die Strukturen der Reaktionsprodukte wurden mittels 13C-NMR aufgeklaert.

Nitriles in Heterocyclic Synthesis: Novel Synthesis of 4H-Thiopyran and of 2-Hydroxy-6-pyridine Thione Derivatives

Reaction of arylmethylenemalononitrile 2a-c with cyanothioacetamide 1 afforded 4-aryl-2,6-diamino-4H-thiopyran-3,5-dicarbonitriles 5a-c on refluxing in ethanolic aqueous triethylamine, rearranged to yield the 4-aryl-1,2-dihydro-6-hydroxy-2-thioxo-3,5-pyridine dicarbonitriles 8a-c.The same compounds could be obtained on treatment of 2a-c with 1 in ethanolic aqueous triethylamine or on reacting 1 with 2d-f.The 13C NMR data of the products are reported and interpreted. - Keywords: Cyanothioacetamide, 2-Aminothiopyranes, Pyridine Thiones, 13C NMR Spectra

A NOVEL SYNTHESIS OF 4-H-THIOPYRANS : UNEXPECTED PRODUCTS OF REACTION OF CYANOTHIOACETAMIDE WITH CINNAMONITRILE DERIVATIVES

The reaction of arylidenemalononitrile with cynothioacetamide afforded either thiopyrans or pyridine derivatives depending on reaction conditions. 13 C NMR was utilised to elucidate the proposed structures of the reaction products.