102432-87-1Relevant articles and documents
Synthesis and pharmacology of N-isomeric quaternary tropane compounds
Nador,Scheiber,Karpati,Grober
, p. 1324 - 1327 (2007/10/02)
The synthesis of (8r)-8-(4-biphenylmethyl)-atropinium bromide (3) as N-isomeric form of xenytropium bromide, (8s)-8-(4-biphenylmethyl)-atropinium bromide (2), is reported. It was revealed, that the equatorial alkylation predominates in quaternization of tertiary tropane compounds. Furthermore, the preparation of other N-isomeric pairs of quaternary tropane derivatives in pure form is described. Xenytropium bromide is more active - 16 times on the parasympathetic end-plate and 8 times on the ganglion - than its N-isomer.