1024346-65-3Relevant academic research and scientific papers
SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS
-
Paragraph 00236-00237, (2013/09/12)
Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper- mineralization.
Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
Dahl, Russell,Sergienko, Eduard A.,Su, Ying,Mostofi, Yalda S.,Yang, Li,Simao, Ana Maria,Narisawa, Sonoko,Brown, Brock,Mangravita-Novo, Arianna,Vicchiarelli, Michael,Smith, Layton H.,O'Neill, W. Charles,Millán, José Luis,Cosford, Nicholas D. P.
experimental part, p. 6919 - 6925 (2010/04/24)
We report the characterization and optimization of drug-like smallmolecule inhibitors of tissue-nonspecific alkaline phosphatase (TNAP), an enzyme critical for the regulation of extracellular matrix calcification during bone formation and growth.High-thro
