102437-03-6

Basic information

• Product Name: methyl 4-(tosyloxy)cyclohexane-1-carboxylate
• Synonyms: methyl 4-(tosyloxy)cyclohexane-1-carboxylate
• CAS NO: 102437-03-6
• Molecular Weight: 312.387
• Mol File: 102437-03-6.mol

Chemical Properties

• CAS DataBase Reference: methyl 4-(tosyloxy)cyclohexane-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(tosyloxy)cyclohexane-1-carboxylate(102437-03-6)
• EPA Substance Registry System: methyl 4-(tosyloxy)cyclohexane-1-carboxylate(102437-03-6)

Safety Data

• Hazardous Substances Data: 102437-03-6(Hazardous Substances Data)

Upstream product

• 99-96-7 4-hydroxy-benzoic acid 
• 3685-22-1 4-hydroxycyclohexanecarboxylic acid 
• 3618-03-9 methyl 4-hydroxycyclohexanecarboxylate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 128208-09-3 methyl trans-4-(4-chlorophenyl)cyclohexane-1-carboxylate 
• 102437-04-7 4-carbomethoxy-2-allylcyclohexanol 
• 6493-77-2 methyl cyclohex-3-ene-1-carboxylate 

Relevant articles and documents

SUBSTITUTED 5-CYANOINDOLE COMPOUNDS AND USES THEREOF

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) - mediated diseases or disorders, Formula (I), wherein R1, R2, R3, R4, and R5 are as defined herein.

A pharmaceutical intermediate 4 - (4 - chlorophenyl) cyclohexyl -1 - formic acid

The invention belongs to the field of preparation of drug intermediates and particularly relates to a synthesis method of a drug intermediate 4-(4-chlorphenyl) cyclohexyl-1-formic acid. The method comprises the following steps: firstly reacting a compound I with R2SO2Cl in the presence of an acid-binding agent to obtain a compound II; carrying out catalytic coupling reaction on the compound II and a Grignard reagent 4-chlorphenyl magnesium halide under the action of a catalyst to obtain a compound III; and finally hydrolyzing the compound III in alkali liquor to obtain a target product 4-(4-chlorphenyl) cyclohexyl-1-formic acid. According to the synthesis method, all steps in a reaction route are exclusive reactions; and ortho-position and meta-position problems in friedel-crafts reaction are overcome, so that the utilization rate of raw materials is high; the total yield is high; and the cost is low. A main body structure is constructed by a coupling technique, so that the problem that hydrolysate which is formed after a lot of lewis acid used in the friedel-crafts reaction is hydrolyzed needs to be subjected to special treatment is overcome; the method is environment-friendly; and industrialized production is facilitated.

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

General Syntheses of 6- and 7-Carbomethoxy-trans-1-heteradecalins and 6- and 7-Carbomethoxy-trans-2-heteradecalins

Two routes to all of the title compounds in the oxa and aza series have been studied.The most general path, involving a cyclohexene oxide intermediate, was not successful becauase of difficulty in separating regioisomers.Allylation of 4-carbomethoxycyclohexanone (11) followed by reduction produced the required trans-disubstituted allyl alcohols, which were converted to all of the desired 6-carbomethoxy-trans-1-heteradecalins.The allyl ketones were subjected to a homologation-side chain contraction sequence to produce the 6-carbomethoxy-trans-2-heteradecalins.Allylation of 3-carbomethoxycyclohexanone (12) was not regioselective, but all four product isomers were characterized.The desired 5-carbomethoxy-2-allylcyclohexanone isomers (27 and 28) were converted to the 7-carbomethoxy-trans-decalins by similar series of reactions