102437-80-9Relevant academic research and scientific papers
Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemobiosynthetic approach
Mancuso, Lena,Knobloch, Tobias,Buchholz, Jessica,Hartwig, Jan,M?ller, Lena,Seidel, Katja,Collisi, Wera,Sasse, Florenz,Kirschning, Andreas
, p. 17541 - 17551 (2014)
A combination of mutasynthesis, precursor-directed biosynthesis and semisynthesis provides access to new ansamitocin derivatives including new nanostructured particle-drug conjugates. These conjugates are based on the toxin ansamitocin and superparamagnetic iron oxide-silica core shell particles. New ansamitocin derivatives that are functionalized either with alkynylor azido groups in the ester side chain at C-3 are attached to nanostructured iron oxide core-silica shell particles. Upon exposure to an oscillating electromagnetic field these conjugates heat up and the ansamitocin derivatives are released by a retro-Diels-Alder reaction. For example, one ansamitocin derivative exerts strong antiproliferative activity against various cancer cell lines in the lower nanomolar range while the corresponding nanostructured particle-drug conjugate is not toxic. Therefore, these new conjugates can serve as dormant toxins that can be employed simultaneously in hyperthermia and chemotherapy when external inductive heating is applied.
Design, synthesis and application of new bile acid ligands with 1,2,3-triazole ring
Pospieszny, Tomasz,Pakiet, Marta,Kowalczyk, Iwona,Brycki, Bogumi?
, p. 81 - 93 (2017)
New dimers have been obtained from propargyl ester of bile acids and α,α′-diazide-m-xylene by intermolecular 1,3-dipolar cycloaddition. These compounds have been used as ligands to form intermolecular hydrogen bonds with various aromatic acids. The struct
Design, synthesis, and self-assembling properties of novel triazolophanes
Haridas,Lal, Kashmiri,Sharma, Yogesh K.,Upreti, Shailesh
, p. 1645 - 1647 (2008)
A series of novel triazolophanes containing peptidic and nonpeptidic backbones is reported. The crystal structure of one such macrocycle displays self-assembly through nonconventional hydrogen-bonding interactions.
Design, synthesis, antimicrobial evaluation and in silico studies of symmetrical bis (urea-1,2,3-triazole) hybrids
Poonia, Nisha,Lal, Kashmiri,Kumar, Ashwani
, p. 1087 - 1103 (2021)
Abstract: In search of 1,2,3-triazole-based antimicrobials, some symmetrical bis(urea-1,2,3-triazole) hybrids were synthesized via clicked Huisgen cycloaddition. The structural characterization was done by different physical and spectral techniques like N
Phosphatidylcholine-derived bolaamphiphiles via click chemistry
O'Neil, Edward J.,DiVittorio, Kristy M.,Smith, Bradley D.
, p. 199 - 202 (2007)
(Chemical Equation Presented) The copper-catalyzed azide alkyne cycloaddition is employed to modify phosphatidylcholine precursors with sn-2 acyl chains containing terminal alkyne or azide groups. Although the reactions are conducted as biphasic dispersio
Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications
Ashmus, Roger A.,Busmann, Jil A.,Davies, Gideon J.,Foster, Leonard J.,García Fernández, José M.,González-Cuesta, Manuel,Madden, Zarina,Males, Alexandra,Ortiz Mellet, Carmen,Proceviat, Cameron,Rogalski, Jason C.,Sidhu, Peter,Vocadlo, David J.
supporting information, p. 832 - 844 (2022/01/19)
Owing to its roles in human health and disease, the modification of nuclear, cytoplasmic, and mitochondrial proteins with O-linked N-acetylglucosamine residues (O-GlcNAc) has emerged as a topic of great interest. Despite the presence of O-GlcNAc on hundre
Charge neutral halogen bonding tetradentate-iodotriazole macrocycles capable of anion recognition and sensing in highly competitive aqueous media
Beer, Paul D.,Boonpalit, Kajjana,Bunchuay, Thanthapatra,Docker, Andrew,Ruengsuk, Araya,Sukwattanasinitt, Mongkol,Surawatanawong, Panida,Tantirungrotechai, Jonggol
supporting information, p. 11976 - 11979 (2021/12/01)
A series of neutral tetradentate halogen bonding (XB) macrocycles, comprising of two bis-iodotriazole XB donors were synthesised in 60-70% yields via a stepwise CuAAC-mediated cyclisation strategy. Extensive 1H NMR anion titration experiments reveal halide binding affinities are critically dependent on the substitution pattern of the xylyl spacer unit. The meta-substituted macrocycle remarkably displays cooperative tetradentate XB-halide anion recognition in highly competitive 40% aqueous-organic D2O/acetone-d6 (40?:?60, v/v) solvent mixtures. Integration of para-xylyl and naphthyl spacer units generates extended macrocyclic cavities, capable of selective oxalate recognition. Furthermore, preliminary fluorescence exeperiments reveal dicarboxylate specific sensing can be achieved through monitoring of the naphthylene centred emission. This journal is
Synthesis, anti-microbial activity and molecular docking studies on triazolylcoumarin derivatives
Satheeshkumar, Chinnadurai,Ravivarma, Mahalingam,Arjun, Pandian,Silambarasan, Vaithiyanathan,Raaman, Nanjian,Velmurugan, Devadasan,Song, Changsik,Rajakumar, Perumal
, p. 565 - 571 (2015/05/20)
A series of triazolylcoumarins was synthesized by the cycloaddition of acetylenic derivatives to azide in the presence of Cu(I) catalyst at room temperature. All the synthesized compounds were evaluated for their anti-microbial activity against Gram-posit
Detection of Zn(II) ions by fluorescent pyrene-derived molecular probes
Manandhar, Erendra,Cragg, Peter J.,Wallace, Karl J.
, p. 141 - 150 (2014/05/06)
Two pyrene-based molecular probes have been synthesised from ortho-and meta-bis(azidodimethyl)benzene and their coordination with Fe(III), Al(III), Fe(II), Zn(II), Ni(II), Cu(II), Cd(II), Hg(II), Ca(II), Mg(II) and Na(I) cations is described. The greatest
Bi- and tri-metallic Rh and Ir complexes containing click derived bis- and tris-(pyrazolyl-1,2,3-triazolyl) N-N′ donor ligands and their application as catalysts for the dihydroalkoxylation of alkynes
Vuong, Khuong Q.,Wong, Chin M.,Bhadbhade, Mohan,Messerle, Barbara A.
supporting information, p. 7540 - 7553 (2014/05/20)
A series of bi-topic and tri-topic pyrazolyl-1,2,3-triazolyl donor ligands (1a-d; 1a-c = 1,X-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl) benzene (X = 2, 3 and 4; o-C6H4(PyT)2, m-C 6H4/su
