1220124-58-2Relevant academic research and scientific papers
The sequential building of chiral macrocyclic Bis-β-Lactams by double staudinger-Cu-Catalyzed azide-Alkyne Cycloadditions
Pellico, Daniel,Gomez-Gallego, Mar,Ramirez-Lopez, Pedro,Mancheno, Maria Jose,Sierra, Miguel A.,Rosario Torres
supporting information; experimental part, p. 1592 - 1600 (2010/06/17)
A novel approach for the synthesis of macrocyclic bis-β-lactams based on the Cu-catalyzed alkyne-azide cycloaddition (CuAAC) is reported. The procedure is general and allows access to a full range of diastereomerically or enantiomerically pure macrocyclic cavities in good yields. The incorporation of chiral oxazolidinone fragments at C3 in the β-lactam rings allows the total enantiocontrol of the process.
