102445-61-4Relevant academic research and scientific papers
An efficient and chemoselective method for protection of thiols catalyzed by aluminumdodecatungstophosphate (AlPW12O40), as a highly water tolerant Lewis acid catalyst
Firouzabadi, Habib,Iranpoor, Nasser,Jafari, Abbas Ali
, p. 2683 - 2686 (2005)
Protection of various thiols with diphenylmethanol was achieved in high yields at room temperature using catalytic amounts of AlPW12O 40 in CH2Cl2. In the presence of this catalyst, protection of SH versus OH was achieved with high chemoselectivity and yields. The catalyst can be easily recovered and reused. Deprotection of DPM thioethers was also achieved using molecular iodine at reflux in CH2Cl 2 in high yields.
Rapid formation of diphenylmethyl ethers and thioethers using microwave irradiation and protic ionic liquids
Altimari, Jarrad M.,Delaney, Joshua P.,Servinis, Linden,Squire, Jennifer S.,Thornton, Megan T.,Khosa, Simren K.,Long, Benjamin M.,Johnstone, Mark D.,Fleming, Cassandra L.,Pfeffer, Frederick M.,Hickey, Shane M.,Wride, Matthew P.,Ashton, Trent D.,Fox, Bronwyn L.,Byrne, Nolene,Henderson, Luke C.
supporting information; experimental part, p. 2035 - 2039 (2012/07/17)
Using microwave irradiation and protic ionic liquids (pIL) as co-solvent and catalyst for the synthesis of several diphenylmethyl ethers was achieved. The desired ethers were isolated simply by filtration through a silica plug to remove the pIL and proceeded in high yields (60-98%). These reactions were extremely rapid (10-30 min) and occurred under mild conditions (80 °C). This protocol was also successfully applied to the synthesis of thioethers.
