102451-67-2Relevant academic research and scientific papers
Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles
Aksenov, Alexander V.,Aksenov, Dmitrii A.,Arutiunov, Nikolai A.,Aksenov, Nicolai A.,Aleksandrova, Elena V.,Zhao, Zhenze,Du, Liqin,Kornienko, Alexander,Rubin, Michael
, p. 7123 - 7137 (2019)
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells.
Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
Aksenov, Alexander V.,Aksenov, Dmitrii A.,Aksenov, Nicolai A.,Aleksandrova, Elena V.,Grishin, Igor Yu.,Rubin, Michael,Sorokina, Elena A.,Wenger, Allison
, (2021/10/20)
The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein,
Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility
Schaffer, Peter C.,Kulkarni, Pushkar M.,Janero, David R.,Thakur, Ganesh A.
, (2020/09/11)
Specific tuning of cannabinoid 1 receptor (CB1R) activity by small-molecule allosteric modulators is a therapeutic modality with multiple properties inherently advantageous to therapeutic applications. We previously generated a library of unique CB1R posi
Efficient synthesis of 3-substituted indoles through a domino gold(I) chloride catalyzed cycloisomerization/C3-functionalization of 2-(alkynyl)anilines
Praveen,Karthikeyan,Perumal
experimental part, p. 9244 - 9255 (2010/01/16)
An efficient synthesis of 3-substituted indoles by a sequential approach involving gold(I) chloride catalyzed cycloisomerization/bis-addition and conjugate addition of 2-(alkynyl)anilines has been accomplished. A variety of 2-(alkynyl)anilines, aldehydes,
