1024585-60-1

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• 3006-96-0 3-hydroxymethyl-benzoic acid 
• 88-15-3 2-Acetylthiophene 
• 34772-98-0 3-dimethylamino-1-thiophen-2-ylpropenone 
• 154321-60-5 4-thiophen-2-yl-pyrimidin-2-ylamine 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 99-99-0 1-methyl-4-nitrobenzene 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 1451042-77-5 2-(5-amino-2-methylphenylamino)pyrimidin-4-one 
• 1025717-41-2 2-(2-methyl-5-nitrophenylamino)pyrimidin-4-one 
• 6165-68-0 thiophene boronic acid 
• 1451042-78-6 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[(4-oxo-2-pyrimidinyl)amino]-phenyl]benzamide 

Relevant academic research and scientific papers

INTERMEDIATES FOR A NOVEL PROCESS OF PREPARING IMATINIB AND RELATED TYROSINE KINASE INHIBITORS

4-Oxo-2-phenylaminopyrimidine derivatives as intermediates for synth of tyrosine kinase inhibitors, in particular imatinib and nilotinib.

A facile total synthesis of imatinib base and its analogues

Imatinib and its analogues were successfully synthesized by an improved method in 19.5-46.2% total yield of six main steps. Pyrimidinyl amine was prepared by the reaction of enaminone and guanidine nitrate without the use of a toxic cyanamide. N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl) pyrimidin-2-amine as a key intermediate for the synthesis of imatinib was prepared by coppercatalyzed iV-arylation of heteroarylamme in 82% yield. The copper salts were used instead of the expensive palladium compounds in this C-N bond-forming reaction. The intermediate nitro compound was reduced by a N2H 4.H2O/FeCl3/C system using water as a solvent in good yield.