1024585-99-6Relevant academic research and scientific papers
Direct cross-coupling of C-H bonds with grignard reagents through cobalt catalysis
Li, Bin,Wu, Zhen-Hua,Gu, Yi-Fan,Sun, Chang-Liang,Wang, Bai-Quan,Shi, Zhang-Jie
supporting information; experimental part, p. 1109 - 1113 (2011/04/22)
Go go Grignard! The first highly regioselective, cobalt-catalyzed C-H transformation of benzo[h]quinoline and phenylpyridine derivatives with Grignard reagents at room temperature has been achieved (see scheme). Both aryl and alkyl Grignard reagents showed significant reactivity.
Iron-catalyzed direct arylation through directed C-H bond activation
Norinder, Jakob,Matsumoto, Arimasa,Yoshikai, Naohiko,Nakamura, Eiichi
, p. 5858 - 5859 (2008/09/19)
An iron-catalyzed C-C bond formation reaction of a nitrogen-containing aromatic compound with an arylzinc reagent takes place at 0 °C in a good to quantitative yield. The reaction involves a C-H bond activation directed by a neighboring nitrogen atom. The important additives in this reaction are 1,10-phenanthroline, tetramethylethylenediamine, and 1,2-dichloro-2-methylpropane, in the absence of which a very low product yield was observed. Copyright
