1024593-51-8Relevant academic research and scientific papers
Thiamine hydrochloride (VB1) as an efficient promoter for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Chen, Yijia,Shan, Weiguang,Hu, Lihong,Lei, Min
, p. 5923 - 5925,3 (2012)
A facile, efficient, and environmentally friendly procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from isatoic anhydride, aldehyde, and ammonium acetate in the presence of thiamine hydrochloride (VB1) in EtOH is described. The p
Electrostatically Enhanced Sulfuric Acid: A Strong Br?nsted Acidic Catalyst for Multi-Component Reactions
Anzabi, Mohadese Yaghoobi,Yazdani, Hossein,Bazgir, Ayoob
, p. 1934 - 1940 (2019/04/25)
Abstract: A new electrostatically enhanced sulfuric acid as a strong Br?nsted acidic catalyst has been developed for multi-component reactions. A positively charged center in the catalyst electrostatically activates it for acid-catalyzed multi-component reactions and afforded desired products in short reaction time and near room temperature in EtOH as a green solvent. Graphical Abstract: [Figure not available: see fulltext.].
Convenient and Scalable Synthesis of 2,3-Dihydroquinazolin-4(1 H)-one Derivatives and Their Anticancer Activities
Rajaka, Lingayya,Penumati, Nageshwar Rao,Nagaiah,Poornachandra,Kumar, C. Ganesh
supporting information, p. 1893 - 1901 (2015/08/03)
An efficient and mild InBr3-catalyzed approach to synthesize 2,3-dihydroquinazolin-4(1H)-one derivatives (3a-3aa) has been developed. Notably, all the products were isolated by recrystallization and the reaction is accessible on a gram scale. Moreover, the reactions only require 10-60 min. All the synthesized compounds were evaluated for their in vitro anticancer activity against four human cancer cell lines.
Highly efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by heteropoly acids in water
Zong, Ying Xiao,Zhao, Yan,Luo, Wen Cai,Yu, Xing Hai,Wang, Jun Ke,Pan, Yi
experimental part, p. 778 - 781 (2011/11/12)
Heteropoly acids efficiently catalyzed the cyclocondensation reaction of anthranilamide with aldehydes in water at ambient temperature and afforded the corresponding 2,3-dihydro-4(1H)-quinazolinones compounds in good to excellent yields. This method provides mild reaction conditions and clean reaction profiles, using a small quantity of catalyst and a simple workup procedure.
Gallium(III) triflate-catalyzed one-pot selective synthesis of 2,3-dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones
Chen, Jiuxi,Wu, Dengze,He, Fei,Liu, Miaochang,Wu, Huayue,Ding, Jinchang,Su, Weike
, p. 3814 - 3818 (2008/09/21)
A series of 2,3-dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones have been synthesized in good to excellent yields and high selectivity by one-pot reaction using isatoic anhydride, ammonium acetate (or amines), and aldehydes in ethanol or in DMSO under mild conditions, respectively. The reaction was efficiently promoted by 1 mol % Ga(OTf)3 and the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity.
