1024684-33-0Relevant academic research and scientific papers
Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates
Trindade, Alexandre F.,Faulkner, Emily L.,Leach, Andrew G.,Nelson, Adam,Marsden, Stephen P.
, p. 8802 - 8805 (2020)
A strategy for the β-sp3 functionalisation of cyclic amines is described. Regioselective conversion of protected amines to enecarbamates is achieved through electrochemical oxidation; these intermediates can be derivatised by functionalised alkyl halides under photoredox catalysis. The potential of the methods is highlighted by direct growth of a DCP2B-binding fragment. This journal is
Hydroformylation of alkenylamines. Concise approaches toward piperidines, quinolizidines, and related alkaloids
Airiau, Etienne,Girard, Nicolas,Pizzeti, Marianna,Salvadori, Jessica,Taddei, Maurizio,Mann, Andre
supporting information; experimental part, p. 8670 - 8673 (2011/02/28)
Linear hydroformylation of N-protected allyl- or homoallylamines (cyclohydrocarbonylation: CHC), followed by a reductive amination constitute the two key steps toward convenient routes to aza-heterocycles.
High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines
Libendi, Samuel S.,Demizu, Yosuke,Matsumura, Yoshihiro,Onomura, Osamu
, p. 3935 - 3942 (2008/09/20)
N-Protecting groups of α-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into α′-methoxylated compounds, while N-cyano derivatives changed into α-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the α-methoxylated compounds protected with cyano group afforded α,α-disubstituted cyclic amines.
