10248-89-2Relevant academic research and scientific papers
Green process development for the synthesis of aliphatic symmetrical N,N'-disubstituted thiourea derivatives in aqueous medium
Jangale, Asha D.,Kumavat, Priyanka P.,Wagh, Yogesh B.,Tayade, Yogesh A.,Mahulikar, Pramod P.,Dalal, Dipak S.
, p. 236 - 244 (2015)
A highly efficient green process for the synthesis of N,N'-disubstituted aliphatic thiourea derivatives using primary aliphatic amines and carbon disulfide in aqueous medium at room temperature via a nonisothiocyanate route is described. This protocol illustrates the rapid preparation of N,N'-disubstituted aliphatic thiourea derivatives in excellent yields with some advantages such as no catalyst and simple workup without any side product formation. Moreover the new route is concise, chromatography-free, and adaptable to pilot-scale preparation.
Green Process Development for the Synthesis of Aliphatic Symmetrical N,N ′-Disubstituted Thiourea Derivatives in Aqueous Medium
Jangale, Asha D.,Kumavat, Priyanka P.,Wagh, Yogesh B.,Tayade, Yogesh A.,Mahulikar, Pramod P.,Dalal, Dipak S.
, p. 376 - 385 (2015)
A highly efficient green process for the synthesis of N,N′-disubstituted aliphatic thiourea derivatives using primary aliphatic amines and carbon disulfide in an aqueous medium at room temperature via a nonisothiocyanate route is described. This protocol illustrates the rapid preparation of N,N′-disubstituted aliphatic thiourea derivatives in excellent yields with some advantages such as no catalyst and simple workup without any side product formation. Moreover, the new route is concise, does not require chromatography, and is adaptable to pilot-scale preparation. GRAPHICAL ABSTRACT.
Synthesis of thioureas in ionic liquid medium
Halimehjani, Azim Ziyaei,Farahbakhsh, Fataneh
, p. 284 - 288 (2013/08/26)
A highly efficient procedure for the synthesis of symmetrical thioureas by means of simple condensation of primary amines and carbon disulfide in 1-butyl-3-methylimidazolium chloride [BMIM][Cl] as a cheap and commercially available ionic liquid is presented. This procedure works for aromatic and aliphatic primary amines and give high to excellent yields of symmetrical thioureas without need for any catalyst or tedious work-up.
A concise synthesis of substituted thiourea derivatives in aqueous medium
Maddani, Mahagundappa R.,Prabhu, Kandikere R.
supporting information; experimental part, p. 2327 - 2332 (2010/07/02)
(Figure Presented) An efficient method for the synthesis of symmetrical and unsymmetrical substituted thiourea derivatives by means of simple condensation between available building blocks such as amines and carbon disulfide in aqueous medium is presented. This protocol works smoothly with aliphatic primary amines to afford various di- and trisubstituted thiourea derivatives. The present method is also useful in synthesizing various substituted 2-mercapto imidazole heterocycles. This method proceeds through a xanthate (amino dithiol deivative) intermediate, unlike isothiocyanate as in an earlier known method.
1-(Methyldithiocarbonyl)imidazole as thiocarbonyl transfer reagent: A facile one-pot three-component synthesis of 3,5- and 1,3,5-substituted-2- thiohydantoins
Sundaram,Venkatesh,Ila,Junjappa
, p. 251 - 254 (2007/10/03)
An efficient three-component one-pot synthesis of 3,5-and 1,3,5-substituted 2-thiohydantoins employing easily accessible amino acid esters, primary amines and 1-(methyldithiocarbonyl)imidazole as thiocarbonyl transfer reagent has been reported. Georg Thieme Verlag Stuttgart.
Study on the decomposition products of thiadiazinthione and their anticancer properties
Perez,Rodriguez,Perez,Suarez,Reyes,Gonzalez,Lopez de Cerain,Ezpelata,Perez,Ochoa
, p. 854 - 857 (2007/10/03)
Study of the anticancer properties of thirty-four 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives has been carried out by using cytotoxicity assays against HeLa, HT-29 and Hep G2 cells. The decomposition products of thiadiazinthione 1m have been studied and their anticancer properties evaluated.
