1024829-76-2

Upstream product

• 18942-49-9 Boc-D-Phe-OH 
• 92122-45-7 Fmoc-D-Lys(BOC)-OH 
• 35661-60-0 N-(9-fluorenylmethoxycarbonyl)-D-leucine 
• 86123-10-6 Fmoc-D-Phe-OH 
• 28862-79-5 Z-D-Leu-OH 
• 63328-49-4 (R)-2-amino-6-tert-butoxycarbonylaminohexanoic acid methyl ester 
• 1024829-73-9 C₄₃H₆₃N₅O₉ 
• 66494-53-9 methyl N₆-(tert-butoxycarbonyl)-D-lysinate hydrochloride 
• 125511-89-9 methyl (R)-2-((R)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-3-phenylpropanoate 
• 21685-51-8 D-phenylalanine methyl ester 
• 1024829-72-8 (R)-2-((R)-2-((R)-2-tert-butyloxycarbonylamino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylvaleric acid 

Relevant academic research and scientific papers

POLYPEPTIDE COMPOUND, PHARMACEUTICAL COMPOSITION, PREPARATION METHOD AND APPLICATION THEREOF

The present invention discloses a polypeptide compound, a pharmaceutical composition, and a preparation method and use thereof. The structural formula of the polypeptide compound is shown in general formula (I): Such polypeptide compounds as κ-opioid receptor agonists have the advantages of better activity and the potential to become clinical candidate compounds.

KAPPA OPIOID RECEPTOR PEPTIDE AMIDE AGONISTS

The present invention provides kappa opioid receptor peptide agonists, methods for preparing these compounds, compositions comprising these kappa opioid receptor peptide agonists, and methods of using the kappa opioid receptor peptide agonists to treat pain or other conditions.

PEPTIDE AMIDE COMPOUND AND PREPARATION METHOD AND MEDICAL USE THEREOF

The invention provides a peptide amide compound represented by the general general formula (I), a preparation method thereof, and a medical application thereof. The compound has a novel structure, better biological activity, and better analgesic effect.

Synthetic peptide amides

The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure of formula I: Pharmaceutical compositions containing these compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. Such treatable pain includes visceral pain, neuropathic pain and hyperalgesia. Inflammation associated with conditions such as IBD and IBS, ocular and otic inflammation, other disorders and conditions such as pruritis, edema, hyponatremia, hypokalemia, ileus, tussis and glaucoma are treatable or preventable with the pharmaceutical compositions of the invention.