(2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

Base Information

Chemical Name:(2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid
CAS No.:1024829-76-2
Molecular Formula:C₄₀H₅₉N₅O₉
Molecular Weight:753.937
Hs Code.:

(2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

Synonyms:(2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

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Chemical Property of (2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

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Technology Process of (2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

There total 17 articles about (2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: methyl (2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoate

: 1024829-76-2
(2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In methanol; water; at 0 - 25 ℃; for 4h;

Reference yield: 80.0%

: 1024829-73-9
C₄₃H₆₃N₅O₉

: 1024829-76-2
(2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

Guidance literature:: With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; at 0 - 20 ℃; for 3h;

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 92122-45-7
Fmoc-D-Lys(BOC)-OH

: 35661-60-0,126727-03-5,114360-54-2
N-(9-fluorenylmethoxycarbonyl)-D-leucine

: 86123-10-6
Fmoc-D-Phe-OH

: 1024829-76-2
(2R)-6-(tert-butoxycarbonylamino)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

Guidance literature:: Fmoc-D-Lys(BOC)-OH; With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; at 20 ℃; for 2.5h; 2-chlorotritylchloride resin

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Boc-D-Phe-OH; N-(9-fluorenylmethoxycarbonyl)-D-leucine; Fmoc-D-Phe-OH; Further stages;