102492-71-7Relevant academic research and scientific papers
Synthesis and Antiinflammatory / Analgesic Activities of 11H-Dibenzodioxepinacetic Acids
Hagmann, William K.,Dorn, Conrad P.,Frankshun, Robert A.,O'Grady, Laura A.,Bailey, Philip J.,et al.
, p. 1436 - 1441 (1986)
A new class of tricyclic arylacetic acids was synthesized and evaluated as antiinflammatory / analgesic agents as well as inhibitors of prostaglandin synthetase. 11H-Dibenzodioxepin-2-, -3-, -7-, and -8-acetic and α-methylacetic acids and their
Industrial preparation method of 2,4,5-trifluorophenylacetic acid
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Paragraph 0041; 0054, (2021/03/11)
The invention relates to the technical field of preparation of chemical drug intermediates, and particularly discloses an industrial preparation method of 2,4,5-trifluorophenylacetic acid. The preparation method comprises the following steps: carrying out a nitration reaction, a fluorination reaction, a hydrogenation reduction reaction, a diazotization reaction, a halogenation reaction, a cyaniding reaction, a thermal decomposition reaction and a hydrolysis reaction on 2,4-dichlorotoluene to prepare the 2,4,5-trifluorophenylacetic acid. The method has the advantages of low preparation cost andhigh product yield.
