10250-65-4

Upstream product

• 98-86-2 acetophenone 
• 60-34-4 methylhydrazine 
• 20577-73-5 methyl 4-phenyl-2,4-dioxobutanoate 
• 74641-61-5 N-Methyl-N-nitroso-2-phenylglycin 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 10199-53-8 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid 
• 288249-52-5 N-(3-cyano-4-neopentyloxyphenyl)-1-methyl-5-phenylpyrazole-3-carboxyamide 
• 859850-98-9 1-methyl-5-phenyl-1H-pyrazole-3-carbonyl chloride 

Relevant academic research and scientific papers

AMIDE COMPOUNDS

The present invention provides compounds represented by the formula (Ia) the formula (Ib) the formula (Ic) and the formula (Id) wherein each symbol is as defined in the specification. According to the present invention, these compounds have a DGAT inhibit

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

On the Problem of Regioselectivity in the 1,3-Dipolar Cycloaddition Reaction of Munchnones and Sydnones with Acetylenic Dipolarophiles

The 1,3-dipolar cycloaddition reaction of several unsymmetrically substituted munchnones and sydnones with methyl propiolate has been examined.The initially formed cycloadducts readily extrude carbon dioxide to produce five-membered heteroaromatic ring compounds.The reaction of sydnones with methyl propiolate produced a mixture of regioisomeric pyrazoles.The analogous cycloaddition reaction of munchnones with methyl propiolate proceeds with formation of mixtures of both possible regioisomeric pyrroles.The structural assignment of the isolated adducts is based on spectroscopic data.The distribution of products depends on the nature and location of the substituent groups present on the heterocyclic ring.The observed regioselectivity is discussed on the basis of MO-perturbation theory.