1025044-93-2Relevant academic research and scientific papers
Highly enantioselective tandem enzyme-organocatalyst crossed aldol reactions with acetaldehyde in deep-eutectic-solvents
Müller, Christoph R.,Meiners, Isabell,Domnguez De Mara, Pablo
, p. 46097 - 46101 (2015/02/19)
Deep-eutectic-solvents (DES), e.g. choline chloride and glycerol, have emerged as promising bio-based and cost-effective reaction media. Herein, the first concept of tandem catalysis of enzymes and organocatalysts in such environmentally-friendly DES is r
Chiral primary amine catalyzed asymmetric direct cross-aldol reaction of acetaldehyde
Hu, Shenshen,Zhang, Long,Li, Jiuyuan,Luo, Sanzhong,Cheng, Jin-Pei
experimental part, p. 3347 - 3352 (2011/08/03)
The first primary aminocatalytic direct cross-aldol reaction of acetaldehyde is presented. Among the various vicinal diamines screened, the L-tert-leucine derivative 1c in conjunction with (H4SiW 12O40)0.25 was identified as the optimal catalyst; good catalytic activity (up to 99% yield in 4 h), and high enantioselectivities (up to 92% ee) were achieved for a range of donors, including aromatic aldehydes and isatin derivatives. Aqueous acetaldehyde solution and paraldehyde can be conveniently applied in this system.
A diarylprolinol in an asymmetric, catalytic, and direct crossed-aldol reaction of acetaldehyde
Hayashi, Yujiro,Itoh, Takahiko,Aratake, Seiji,Ishikawa, Hayato
supporting information; experimental part, p. 2082 - 2084 (2009/02/06)
(Chemical Equation Presented) No over-reacting: A diarylprolinol was found to be an effective organocatalyst of the direct, enantioselective aldol reaction of acetaldehyde, affording β-hydroxy α-unsubstituted aldehydes in good yield with excellent enantio
