1025054-90-3

Basic information

• Product Name: 1-chloro-3-Methyl-Pyrrolo[1,2-a]pyrazine
• Synonyms: 1-chloro-3-Methyl-Pyrrolo[1,2-a]pyrazine
• CAS NO: 1025054-90-3
• Molecular Formula: C₈H₇ClN₂
• Molecular Weight: 166.60758
• Mol File: 1025054-90-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.61±0.10(Predicted)
• CAS DataBase Reference: 1-chloro-3-Methyl-Pyrrolo[1,2-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-3-Methyl-Pyrrolo[1,2-a]pyrazine(1025054-90-3)
• EPA Substance Registry System: 1-chloro-3-Methyl-Pyrrolo[1,2-a]pyrazine(1025054-90-3)

Safety Data

• Hazardous Substances Data: 1025054-90-3(Hazardous Substances Data)

Usage

General Description

1-chloro-3-Methyl-Pyrrolo[1,2-a]pyrazine is a chemical compound with the molecular formula C6H5ClN2. It is a heterocyclic aromatic compound that contains a pyrrolopyrazine ring system with a chlorine atom and a methyl group attached. 1-chloro-3-Methyl-Pyrrolo[1,2-a]pyrazine is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs and compounds. It has applications in the development of potential drug candidates for diseases such as cancer, diabetes, and neurological disorders. Additionally, 1-chloro-3-Methyl-Pyrrolo[1,2-a]pyrazine is also used in the research and development of new materials and organic molecules, making it a versatile and important chemical in the field of organic chemistry.

Upstream product

• 116212-48-7 3-methyl-1H-pyrrolo-<2,1-c><1,4>oxazin-1-one 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 1025054-80-1 3-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one 

Downstream Products

• 1025052-53-2 C₁₆H₁₁FN₂ 
• 1025052-56-5 C₁₆H₁₁ClN₂ 
• 1613022-29-9 1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]amide 
• 1613022-31-3 1-phenyl-1H-[1,2,4]triazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-amide 
• 1613022-36-8 1-phenyl-1H-imidazole-4-carboxylic acid[1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-amide 
• 1613022-38-0 C₂₂H₂₁ClN₆O*C₂HF₃O₂ 
• 1613022-42-6 2-phenyloxazole-4-carboxylic acid [1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]amide 
• 1613022-44-8 C₂₂H₂₁N₅OS*C₂HF₃O₂ 
• 1613022-46-0 1-(4-fluorophenyl)-1H-[1,2,4]triazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]amide 
• 1613022-28-8 1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide 
• 1613022-30-2 1-phenyl-1H-[1,2,4]triazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]amide 
• 1613022-35-7 1-phenyl-1H-imidazole-4-carboxylic acid[1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-amide 
• 1613022-37-9 1-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-amide 
• 1613022-41-5 2-phenyloxazole-4-carboxylic acid [1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-amide 

Relevant articles and documents

Development of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists

We describe the synthesis of quinuclidine-containing spiroimidates and their utility as α7 nicotinic acetylcholine receptor (nAChR) partial agonists. A convergent synthetic route allowed for rapid SAR investigation and provided a diverse set of fused 6,5-heteroaryl analogs. Two potent and selective α7 nAChR partial agonists, (1′S,3′R,4′S)-N-(7-bromopyrrolo[2,1-f ][1,2,4]triazin-4-yl)-4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-amine (20) and (1′S,3′R,4′S)-N-(7-chloropyrrolo[2,1-f ][1,2,4]triazin-4-yl)-4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-amine (21), were identified. Both agonists improved cognition in a preclinical rodent model of learning and memory. Additionally, 5-HT3A receptor SAR suggested the presence of a steric site that when engaged led to significant loss of affinity at that receptor.

Phenylethynyl-pyrrolo[1,2-a]pyrazine: A new potent and selective tool in the mGluR5 antagonists arena

The synthesis and the structure activity of a new series of pyrrolo[1,2-a]pyrazine is reported. These molecules are potent and selective non-competitive mGluR5 antagonists and may shed new light on the pattern of substitution tolerated by this receptor.