1025112-89-3

Basic information

• Product Name: {(1R,3S)-3-hexadecanoylamino-1-hydroxy-4-[4-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethoxy)-phenyl]-butyl}-phosphonic acid dimethyl ester
• Synonyms: {(1R,3S)-3-hexadecanoylamino-1-hydroxy-4-[4-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethoxy)-phenyl]-butyl}-phosphonic acid dimethyl ester
• CAS NO: 1025112-89-3
• Molecular Weight: 676.874
• Mol File: 1025112-89-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {(1R,3S)-3-hexadecanoylamino-1-hydroxy-4-[4-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethoxy)-phenyl]-butyl}-phosphonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(1R,3S)-3-hexadecanoylamino-1-hydroxy-4-[4-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethoxy)-phenyl]-butyl}-phosphonic acid dimethyl ester(1025112-89-3)
• EPA Substance Registry System: {(1R,3S)-3-hexadecanoylamino-1-hydroxy-4-[4-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethoxy)-phenyl]-butyl}-phosphonic acid dimethyl ester(1025112-89-3)

Safety Data

• Hazardous Substances Data: 1025112-89-3(Hazardous Substances Data)

Upstream product

• 1025112-88-2 [(1R,3S)-3-hexadecanoylamino-1-hydroxy-4-(4-hydroxyphenyl)-butyl]-phosphonic acid dimethyl ester 
• 86604-78-6 (4-methoxy-3,5-dimethylpyridin-2-yl)methanol 

Downstream Products

• 1025112-90-6 C₃₅H₅₇N₂O₇P 

Relevant articles and documents

α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors

Autotaxin (ATX) is an attractive pharmacological target due to its lysophospholipase D activity which leads to the production of lysophosphatidic acid (LPA). Blockage of ATX produced LPA by small molecules could be a potential anticancer chemotherapy. In our previous study, we have identified the two β-hydroxy phosphonate analogs of LPA (compounds f17 and f18) as ATX inhibitors. With this work, we investigated α- and β-substituted phosphonate analogs of LPA and evaluated them for ATX inhibitory activity. The stereochemistry of β-hydroxy phosphonates was also studied.