86604-78-6

Basic information

• Product Name: 3,5-Dimethyl-4-methoxy-2-pyridinemethanol
• Synonyms: ((4-Methoxy-3,5-dimethyl)-2-pyridinyl)methanol;4-methoxy-3,5-dimethyl-2-pyridylmethanol;PYRMETHYLALCOHOL;2-HYDROXYMETHYL-4-METHOXY-3,5-DIMETHYLPYRIDINE;2-HYDROXYMETHYL-3,5-DIMETHYL-4-METHOXY PYRIDINE;3,5-DIMETHYL-2-HYDROXYMETHYL-4-METHOXYPYRIDINE;3,5-DIMETHYL-4-METHOXY-2-PYRIDINE METHANOL;4-METHOXY-3,5-DIMETHYL-2-HYDROXYMETHYL PYRIDINE
• CAS NO: 86604-78-6
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.21
• EINECS: 289-258-5
• Product Categories: Aromatic alcohols and diols;Pyridines derivates;C9 to C46;Heterocyclic Building Blocks;Pyridines;Pharmaceutical intermediates;OLED materials,pharm chemical,electronic;Heterocycle-Pyridine series
• Mol File: 86604-78-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 56.5-60.5 °C(lit.)
• Boiling Point: 289.1 °C at 760 mmHg
• Flash Point: 128.7 °C
• Appearance: /
• Density: 1.092 g/cm³
• Vapor Pressure: 0.00104mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly)
• PKA: 13.27±0.10(Predicted)
• CAS DataBase Reference: 3,5-Dimethyl-4-methoxy-2-pyridinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethyl-4-methoxy-2-pyridinemethanol(86604-78-6)
• EPA Substance Registry System: 3,5-Dimethyl-4-methoxy-2-pyridinemethanol(86604-78-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 86604-78-6(Hazardous Substances Data)

Usage

Uses

(4-Methoxy-3,5-dimethylpyridin-2-yl)methanol can be used as wear-resistant rubber.

General Description

4-Methoxy-3,5-dimethyl-2-pyridinemethanol is a pyridine derivative.

InChI:InChI=1/C9H13NO2/c1-6-4-10-8(5-11)7(2)9(6)12-3/h4,11H,5H2,1-3H3

Upstream product

• 84006-10-0 (chloromethyl)-4-methoxy-3,5-dimethylpyridine 
• 130000-78-1 (4-methoxy-3,5-dimethylpyridin-2-yl)methanamine 
• 75-09-2 dichloromethane 
• 91219-89-5 3,5-dimethyl-4-methoxypyridine 1-oxide 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 86604-75-3 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride 
• 73590-58-6 omeprazole 
• 150054-50-5 4-chloro-2-hydroxymethyl-3,5-dimethylpyridine 
• 187222-15-7 N-benzyl-2-ethoxycarbonyl-3,5-dimethyl-4-pyridone 
• 187222-16-8 2-Ethoxycarbonyl-3,5-dimethyl-4(1H)-pyridone 
• 187222-13-5 3,5-Dimethyl-2-ethoxycarbonyl-4-pyrone 
• 187222-12-4 3,5-dimethyl-4-oxo-4H-pyran-2-carboxylic acid 
• 187222-17-9 4-Chloro-2-ethoxycarbonyl-3,5-Lutidine 

Downstream Products

• 110464-72-7 4-methoxy-3,5-dimethyl-2-pyridinecarboxaldehyde 
• 1025112-89-3 {(1R,3S)-3-hexadecanoylamino-1-hydroxy-4-[4-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethoxy)-phenyl]-butyl}-phosphonic acid dimethyl ester 
• 1025112-66-6 {(1S,3S)-3-hexadecanoylamino-1-hydroxy-4-[4-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethoxy)-phenyl]-butyl}-phosphonic acid dimethyl ester 
• 73590-85-9 omeprazole sulfide 
• 73590-60-0 2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole 
• 104916-41-8 3,5-dimethyl-4-methoxy-2-cyanopyridine 
• 1544041-48-6 1-(4-chlorophenyl)-3-(4-methoxy-3,5-dimethylpyridin-2-yl)propan-1-one 
• 1544041-44-2 3-(4-methoxy-3,5-dimethylpyridin-2-yl)-1-(p-tolyl)propan-1-one 
• 1099653-07-2 3-(4-methoxy-3,5-dimethylpyridin-2-yl)-1-phenylpropan-1-one 
• 913624-57-4 2-(azidomethyl)-4-methoxy-3,5-dimethylpyridine 
• 1616503-57-1 (4-methoxy-3,5-dimethylpyridin-2-yl)methyl 4-methylbenzenesulfonate 
• 1196886-19-7 2-amino-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol 
• 1196886-17-5 7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol 
• 1196886-14-2 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine 

Relevant articles and documents

Preparation method of omeprazole intermediate

The invention relates to a preparation method of an omeprazole intermediate. According to the method, Nmethoxy-4-methoxy3, 5-dimethyl pyridinium is used as a raw material, metal ions are added as an additive, under the action of persulfate, 2-hydroxymethyl- 3, 5-dimethyl -4methoxypyridine is efficiently prepared, and then the 2-hydroxymethyl -3, 5-dimethyl- 4-methoxypyridine is further converted into 2-chloromethyl -3, 5-dimethyl- 4methoxypyridine hydrochloride. According to the method, the conversion rate, the yield and the quality of the 2-hydroxymethyl- 3, 5-dimethyl -4-methoxy pyridine areremarkably improved, so that the purity of the 2-chloromethyl- 3, 5-dimethyl- 4-methoxy pyridine hydrochloride obtained by further reaction is improved, the impurity content is reduced, the product yield and the production efficiency can be effectively improved, the production capacity is improved, and the production cost is reduced.

Slow, spontaneous degradation of lansoprazole, omeprazole and pantoprazole tablets: Isolation and structural characterization of the toxic antioxidants 3H-benzimidazole-2-thiones

The spontaneous degradation of lansoprazole, omeprazole and pantoprazole tablets upon long-term and forced storage conditions was determined by high performance liquid chromatography (HPLC). The more abundant products could be isolated by liquid chromatography and their molecular weights determined by Mass Spectrometry (MS). Their structures, established according to their spectroscopic data, were compared to those of either the literature or of authentic samples. Thus lansoprazole led mainly to a mixture of 3H-benzimidazole-2-thione (2a) and 3H-benzimidazole-2-one (2c), omeprazole mainly to a mixture of 5-methoxy-3H-benzimidazole-2-thione (1a) and 2-hydroxymethyl-3, 5-dimethyl- 4-methoxypyridine (1b), and pantoprazole, to 5-difluoromethoxy-3H-benzimidazole-2-thione (3a) and 2-hydroxymethyl-3, 4-dimethoxypyridine (3b). Although some of the degradation products had already been observed under different conditions, the detection of benzimidazole-2- thiones is unprecedented and their involvement as possible physiological, yet toxic antioxidants must be emphasized. Plausible, unified mechanisms for the formation of the different degradation products observed herein and in previous papers from the literature are suggested.

Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric H+/K+-ATPase inhibitor

A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/K+-ATPase. Compound 4d exhibited potent in vitro inhibitory activity.