10252-29-6Relevant articles and documents
Sol-gel phase transition induced by fiber-vesicle structural changes in sugar-based bolaamphiphiles
Kobayashi, Hideki,Koumoto, Kazuya,Jung, Jong Hwa,Shinkai, Seiji
, p. 1930 - 1936 (2002)
The research objects of this paper were to design bolaamphiphilic gelators utilizing a sugar family as a source of solvophilic groups and an azobenzene segment as a solvophobic group and to monitor the aggregation mode utilizing the spectroscopic properti
Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy
Liu, Hongmei,Zhang, Ruilong,Niu, Yunwei,Li, Yan,Qiao, Chenmeng,Weng, Jie,Li, Jun,Zhang, Xiaoning,Xiao, Zuobing,Zhang, Xin
, p. 20848 - 20857 (2015)
Hypoxia has a major role in tumor development and resistance to therapy. Therefore, the effective targeting and killing of hypoxic tumor cells is a key to successful tumor control. Here, we report the hypoxia-responsive prodrug micelles to deliver hydrophobic anticancer drug, which can selectively release the drugs to treat hypoxic tumor cells in a combined way. For this purpose, an azobenzene (AZO) bond, which imparts hypoxia sensitivity and specificity as cross linker, conjugated PEG-hexanethiol (PEG-C6) with combretastatin A-4 (CA4) to form PEG-C6-AZO-CA4 amphiphilic molecule. These PEG-C6-AZO-CA4 molecules self-assemble into micelles, which can encapsulate hydrophobic anticancer drug. The drug release behavior from PEG-C6-AZO-CA4 micelles was studied under normoxic or hypoxic conditions and the combinations of CA4 with hydrophobic drugs for tumor treatment in vitro were also investigated. As the first example of using AZO linkages to develop anticancer prodrug micelles as hydrophobic anticancer drugs delivery to kill the hypoxic tumor cells in a combination way, this study establishes PEG-C6-AZO-CA4 micelles as a promising drug delivery platform for hypoxic tumor therapy. This journal is
Static Retention of Dynamic Chiral Arrangements for Achiral Shear Thinning Metal–Organic Colloids
Huang, Jian-Cai,Xiao, Hui,Chen, Zhixin,Zheng, Wenxu,Huang, Chang-Cang,Wu, Shu-Ting,Xie, Zenghong,Zhuang, Naifeng
, p. 14017 - 14024 (2021)
Chiral compounds are known to be important not only because they are the fundamental components of living organisms, but also for their unique chiroptical properties. In recent years, scientists have fabricated several chiral organic supramolecular aggregates by using chiral physical fields, such as vortex flow. Herein, the relationship between dynamic chiroptical properties and rheological nature is discussed, suggesting the shear thinning properties of non-Newtonian fluids might help colloidal particles adopt a chiral arrangement in vortices. Furthermore, the storage modulus of colloids could be increased by adding a linking agent, which successfully kept the dynamic chiroptical properties in the static state. Moreover, the salt effect on the host–guest interaction involved in the colloids was studied, the results suggested a significant enhancement of the transferred dynamic circular dichroism for the achiral guest molecule.
Hypoxia-responsive drug–drug conjugated nanoparticles for breast cancer synergistic therapy
Zhang, Ruilong,Li, Yan,Zhang, Miao,Tang, Qunwei,Zhang, Xin
, p. 30268 - 30276 (2016)
In order to eliminate tumors, it is necessary to kill differentiated cancer cells, cancer stem cells (CSCs) and the “vascular niche” synergistically. Although nanoparticles (NPs) have been used to deliver drugs to the action sites, inert materials with high toxicity may reduce the drug loading content and cause side-effects to kidneys and other organs in the course of degradation and excretion. Here, we report hypoxia-responsive drug–drug conjugated NPs to deliver three drugs to kill differentiated cancer cells, CSCs and the “vascular niche” synergistically, which could selectively release the drugs to treat cells in hypoxic tumors. For this purpose, an azobenzene (AZO) bond imparting hypoxia sensitivity and specificity as a crosslinker conjugated hydrophobic combretastatin A-4 (CA4) with hydrophilic irinotecan (IR) to form IR–AZO–CA4 amphiphilic molecules. These molecules self-assembled into NPs, which could encapsulate hydrophobic anti-CSCs drug cyclopamine (CP). The drug–drug conjugated NPs had high drug loading content. As expected, the AZO linker could be broken under hypoxia conditions and the NPs were disassembled to release drugs quickly. Confocal laser scanning microscopy (CLSM) results indicated that the IR–AZO–CA4/CP NPs could enhance the cellular uptake of drugs and the permeability of drugs to the inner of CSCs, beneficial for tumor therapy. Furthermore, the IR–AZO–CA4/CP NPs could inhibit the migration, invasion and mammosphere formation capacity of CSCs. More importantly, only IR–AZO–CA4/CP NPs could simultaneously inhibit differentiated cancer cells, CSCs and endothelial cells without interference on the cell under a normoxic environment. The present study suggests that the IR–AZO–CA4/CP NPs provide a promising therapeutic approach for anticancer treatment.
Synthesis and photoresponsive study of azobenzene centered polyamidoamine dendrimers
Ghosh, Samaresh,Banthia, Ajit K.,Chen, Zhu
, p. 2889 - 2896 (2005)
A new series of novel polyamidoamine (PAMAM) dendrimers 4, 5 and 6 possessing azobenzene units specifically at the core were prepared and their reversible trans/cis photoisomerization properties were studied. PAMAM dendritic wedges as well as azo-based PAMAM dendrimers were fully characterized by means of FT-IR, NMR (1H and 13C), mass spectrometry (MALDI-MS), thermogravimetric and elemental analysis.
Colorant with double catechol structure, preparation method and applications thereof
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Paragraph 0108; 0113-0114, (2020/05/30)
The invention relates to the technical field of organic colorants, and particularly provides a colorant with a double catechol structure, a preparation method and applications thereof, wherein the colorant has a structural general formula represented by a
